Picoplatin
Based on 1 Customer Validation
Picoplatin (AMD473) is a platinum-based antineoplastic agent. Picoplatin is specifically to circumvent thiol-mediated drug resistance by sterically hindering its reaction with glutathione (GSH) while still retaining the ability to form cytotoxic lesions with DNA.
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- Pureté : 98.5%
- CAS No.: 181630-15-9
- Formule: C6H10Cl2N2Pt
- Masse moléculaire:376.15
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
Essai clinique
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 181630-15-9
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Appearance Solid
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Masse moléculaire 376.15
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Formule C6H10Cl2N2Pt
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Color Light yellow to yellow
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SMILES
[Cl-][Pt+2]([N]1=C(C)C=CC=C1)([NH3])[Cl-]
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Synonyms
AMD473; ZD0473
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
In Vitro:
DMF : 25 mg/mL (66.46 mM; Need ultrasonic; DMSO can inactivate Picoplatin's activity)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocole
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Pureté et documentation
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Fiche technique (270 KB)
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SDS (645 KB)
- English - EN (645 KB)
- Français - FR (645 KB)
- Deutsch - DE (645 KB)
- Norwegian - NO (645 KB)
- Español - ES (645 KB)
- Swedish - SV (645 KB)
- Italian - IT (645 KB)
- Korean - KR (645 KB)
- Portuguese - PT (645 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMF | 1 mM | 2.6585 mL | 13.2926 mL | 26.5851 mL | 66.4628 mL |
| 5 mM | 0.5317 mL | 2.6585 mL | 5.3170 mL | 13.2926 mL | |
| 10 mM | 0.2659 mL | 1.3293 mL | 2.6585 mL | 6.6463 mL | |
| 15 mM | 0.1772 mL | 0.8862 mL | 1.7723 mL | 4.4309 mL | |
| 20 mM | 0.1329 mL | 0.6646 mL | 1.3293 mL | 3.3231 mL | |
| 25 mM | 0.1063 mL | 0.5317 mL | 1.0634 mL | 2.6585 mL | |
| 30 mM | 0.0886 mL | 0.4431 mL | 0.8862 mL | 2.2154 mL | |
| 40 mM | 0.0665 mL | 0.3323 mL | 0.6646 mL | 1.6616 mL | |
| 50 mM | 0.0532 mL | 0.2659 mL | 0.5317 mL | 1.3293 mL | |
| 60 mM | 0.0443 mL | 0.2215 mL | 0.4431 mL | 1.1077 mL |
Picoplatin Related Classifications
HY-131468 Related Classifications
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