Torvutatug
Based on 1 Customer Validation
Torvutatug (AZD5335 Antibody) is a human IgG1 κ monoclonal antibody against FRα, with an IC50 value of 7.4 nM against hFRα. Torvutatug can serve as an ADC antibody for the synthesis of ADC, such as AZD5335. Torvutatug is applicable to ovarian cancer-related research.
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- Pureté : 99.00%
- CAS No.: 2975630-15-8
- Masse moléculaire:145.532 kDa
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
[1]|
FRα 7.4 nM (IC50) |
In Vitro
Torvutatug binds specifically to cynomolgus monkey FRα, and shows no cross-reactivity with non-target folate receptor paralogs or rodent FRα[1].
Torvutatug exhibits similarly high affinity for cynomolgus monkey FRα, but extremely low affinity for mouse FRα[1].
Torvutatug binds to cell-surface FRα with high specificity, and exhibits negligible off-target binding to DLL1 only at extremely high concentrations[1].
Torvutatug (up to 8 h) is rapidly internalized and trafficked to lysosomes in FRα-expressing KB cells, and its internalization level is significantly higher than that of the isotype control antibody[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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IgG1-kappa
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Loaded Torvutatug on ProA biosensor, can bind HY-P70296 FOLR1 Protein, Human (HEK293, His) with an affinity constant of 2.582E-08 M as determined in BLI assay.
Chemical Information
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CAS No. 2975630-15-8
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Appearance Liquid
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Masse moléculaire 145.532 kDa
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Color Colorless to light yellow
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SMILES
[Torvutatug]
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Synonyms
AZD5335 Antibody; INT-019
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Livraison
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
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Fiche technique (258 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
Références
[1]. Zoeller JJ, et al. Derivation of AZD5335, a Novel FRα-Targeted TOP1i-Loaded ADC, for the Treatment of FRα-Expressing Cancers. Clinical cancer research : an official journal of the American Association for Cancer Research. 2025 Dec 15;31(24):5261-5275. [Content Brief]
[3]. Moore KN, et al. Antibody-drug conjugates in gynaecological cancers: opportunities and challenges. Nat Rev Clin Oncol. 2026 Jun 17. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Torvutatug Related Classifications
HY-P991164 Related Classifications
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