Fumonisin B3

Cat. No.: HY-N6726 Purity: 99.51%: Data Sheet
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Fumonisin B3 is an orally active fumonisin Mycotoxin. Fumonisin B3 can be isolated from Fusarium moniliforme, Fusarium proliferatum and Fusarium nygamai. Fumonisin B3 induces precancerous lesions, triggers embryonic death of chicken embryos, causes severe hemorrhage in dead chicken embryos. Fumonisin B3 can be used in studies related to hepatocellular carcinoma.

For research use only. We do not sell to patients.

Fumonisin B3 Chemical Structure

CAS No. : 1422359-85-0

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100 μg		In-stock	Estimated Time of Arrival: December 31

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Human Endogenous Metabolite Microbial Metabolite

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Description

IC₅₀ & Target^[2]

Fungal Metabolite

In Vivo

Fumonisin B3 (added to feed at a concentration of 0.05-0.1%; administered daily; for 15 to 20 days) exhibits carcinogenic initiating activity in rat liver, induces GGT⁺ foci and subsequent hepatocellular nodules, and its activity is highly consistent with that of Fumonisin B1^[1].
Fumonisin B3 (2-16 µg per egg; air sac injection; single dose) induces dose-dependent mortality in broiler chicken embryos, with a mortality rate of 14.6% at 16 µg per egg and 8.0% at 2 µg per egg; it also causes hemorrhage in dead embryos but exerts no teratogenic effect on surviving embryos^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	strain not specified^[1]
Dosage:	0.05%; 0.1%
Administration:	diet; daily; 15 to 20 days
Result:	Induced gamma glutamyltranspeptidase positive (GGT⁺) foci in rat livers following 15 to 20 day dietary exposure. Led to formation of hepatocyte nodules after subsequent AAF/PH treatment. Closely mimicked the short-term toxic and cancer initiating effects of Fumonisin B1.

Animal Model:	Peterson-Arbor Acres broiler embryos (72 h incubated prior to toxin injection)^[2]
Dosage:	2 µg per egg; 16 µg per egg
Administration:	air cell injection; single dose
Result:	Resulted in 8.0% cumulative embryonic mortality at 18 days of incubation, with no significant differences in hatchability and hatching weight compared to controls. Resulted in 14.6% cumulative embryonic mortality at 18 days of incubation, which was significantly higher than control groups but not significantly different from the FB2 treatment group. Caused all mortality within 7 days post-injection, with dead embryos showing severe hemorrhages in the back of the head, neck, and thoracic area. Showed no gross developmental abnormalities and no significant difference in embryonic body weight compared to controls for surviving 18-day embryos.

Molecular Weight

705.83

Formula

C₃₄H₅₉NO₁₄

CAS No.

1422359-85-0

Appearance

Liquid (Density: 1.222 g/cm³)

Color

Colorless to light yellow

SMILES

C[C@@H]([C@H](CCCCCC[C@H](C[C@@H](C[C@@H]([C@@H]([C@@H](CCCC)C)OC(C[C@@H](CC(O)=O)C(O)=O)=O)OC(C[C@@H](CC(O)=O)C(O)=O)=O)C)O)O)N

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Microorganisms

Fusarium moniliforme

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: 99.51%

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Data Sheet (272 KB) SDS (557 KB)

COA (248 KB) HNMR (112 KB) RP-HPLC (325 KB) MS (98 KB)

Handling Instructions (2659 KB)

References

[1]. Gelderblom WC, et al. Fumonisins: isolation, chemical characterization and biological effects. Mycopathologia. 1992;117(1-2):11-16. [Content Brief]

[2]. Henry MH, et al. The toxicity of fumonisin B1, B2, and B3, individually and in combination, in chicken embryos. Poult Sci. 2001 Apr;80(4):401-7. [Content Brief]

Fumonisin B3 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fumonisin B31422359-85-0Fumonisin B 3Fumonisin B-3FungalEndogenous Metaboliteprimary hepatocyte DNA repair assaysratsSalmonella testchicken embryosresistant hepatocytesFusarium moniliformehepatocellular carcinomaFusarium nygamaiFusarium proliferatumpreneoplastic lesionsInhibitorinhibitorinhibit

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