1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. Gavestinel sodium salt

Gavestinel sodium salt (Synonyms: GV 150526)

Cat. No.: HY-107700 Purity: 98.06%
Handling Instructions

Gavestinel (GV 150526) is a potent, selective, orally active and non-competitive antagonist of NMDA receptor. Gavestinel binds to the glycine site of the NMDA receptor, with a pKi of 8.5. Gavestinel can be used for the research of acute ischemic stroke.

For research use only. We do not sell to patients.

Gavestinel sodium salt Chemical Structure

Gavestinel sodium salt Chemical Structure

CAS No. : 153436-38-5

Size Price Stock Quantity
5 mg USD 490 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Gavestinel (GV 150526) is a potent, selective, orally active and non-competitive antagonist of NMDA receptor. Gavestinel binds to the glycine site of the NMDA receptor, with a pKi of 8.5. Gavestinel can be used for the research of acute ischemic stroke[1].

IC50 & Target

pKi: 8.5 (NMDA receptor)[1]

Molecular Weight

397.19

Formula

C18H11Cl2N2NaO3

CAS No.
SMILES

O=C(NC1=CC=CC=C1)/C=C/C2=C(C(O[Na])=O)NC3=CC(Cl)=CC(Cl)=C23

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (251.77 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5177 mL 12.5884 mL 25.1769 mL
5 mM 0.5035 mL 2.5177 mL 5.0354 mL
10 mM 0.2518 mL 1.2588 mL 2.5177 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.29 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.29 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.29 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.06%

References
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Product Name:
Gavestinel sodium salt
Cat. No.:
HY-107700
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