CQ211
Based on 1 Customer Validation
CQ211 is a potent and selective RIOK2 inhibitor with a Kd of 6.1 nM. CQ211 exhibits potent proliferation inhibition activity against multiple cancer cell lines.
For research use only. We do not sell to patients.
- Purity : 99.90%
- CAS No.: 2648986-65-4
- Formula: C26H22F3N7O2
- Molecular Weight:521.49
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
IC50 & Target
|
RIOK2 |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HT-29 | IC50 |
0.38 μM
Compound: 7m ; CQ211
|
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
|
[PMID: 35584513] |
| MKN-1 | IC50 |
0.61 μM
Compound: 7m ; CQ211
|
Antiproliferative activity against human MKN-1 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human MKN-1 cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
|
[PMID: 35584513] |
| MKN-1 | IC50 |
1.69 μM
Compound: 7; CQ211
|
Antiproliferative activity against human MKN-1 cells assessed as inhibition of cell proliferation by CCK8 assay
Antiproliferative activity against human MKN-1 cells assessed as inhibition of cell proliferation by CCK8 assay
|
[PMID: 37859717] |
| MOLT-4 | IC50 |
2.12 μM
Compound: 7; CQ211
|
Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell proliferation by CCK8 assay
Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell proliferation by CCK8 assay
|
[PMID: 37859717] |
| U-87MG ATCC | IC50 |
1.65 μM
Compound: 7; CQ211
|
Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell proliferation by CCK8 assay
Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell proliferation by CCK8 assay
|
[PMID: 37859717] |
In Vitro
CQ211 (0-5.0 μM; 4 h) suppresses the phosphorylation of mTOR in cancer cells[1].
CQ211 can obviously suppress the proliferation of MKN-1 and HT-29 cells with IC50 values of 0.61 μM and 0.38 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MKN-1 and HT-29 cells
-
Concentration:0, 0.3, 0.6, 1.2, 2.5, and 5.0 μM
-
Incubation Time:4 h
-
Result:Suppresseed the phosphorylation of mTOR in cancer cells.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Female CB17-SCID mice (6-8 weeks of age) injected wtih MKN-1 cells[1]
-
Dosage:25 mg/kg
-
Administration:Intraperitoneal administration; for 18 consecutive days; once daily
-
Result:Inhibited the tumor progression with tumor growth inhibition (TGI) of 30.9%.
Chemical Information
-
CAS No. 2648986-65-4
-
Appearance Solid
-
Molecular Weight 521.49
-
Formula C26H22F3N7O2
-
Color Off-white to light yellow
-
SMILES
O=C1C2=C(C3=CC(C4=CC=C(N=C4)OC)=CC=C3N1)N(N=N2)C5=CC=C(C(C(F)(F)F)=C5)N6CCNCC6
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro:
DMSO : 12.5 mg/mL (23.97 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (284 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9176 mL | 9.5879 mL | 19.1758 mL | 47.9396 mL |
| 5 mM | 0.3835 mL | 1.9176 mL | 3.8352 mL | 9.5879 mL | |
| 10 mM | 0.1918 mL | 0.9588 mL | 1.9176 mL | 4.7940 mL | |
| 15 mM | 0.1278 mL | 0.6392 mL | 1.2784 mL | 3.1960 mL | |
| 20 mM | 0.0959 mL | 0.4794 mL | 0.9588 mL | 2.3970 mL |
CQ211 Related Classifications
HY-147655 Related Classifications
Powered by Bioz