Dekavil
Dekavil (F8-IL10, PF-06687234) is an agent targeting the IL10 receptor (IL10 receptor) that mediates anti-inflammatory cytokine signaling. Dekavil can induce cytokine-dependent mast cell proliferation. Dekavil can inhibit the progression of established collagen-induced arthritis, reduce plasma levels of pro-inflammatory IL-6 and IL-1 beta, and decrease the infiltration of leukocytes, natural killer cells, macrophages, and T cells into the arthritic paws. Dekavil can be used in research on rheumatoid arthritis.
For research use only. We do not sell to patients.
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Species Reactivity
Human
IC50 & Target
[1]|
IL-10 |
IL-6 |
IL-1β |
In Vitro
Dekavil (up to 100 ng/mL IL10 equivalent; 48 h) exhibited biological activity comparable to recombinant human IL10 in the MC/9 mouse mast cell proliferation assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:DBA/1 (male, 8 to 10 weeks old)[1]
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Dosage:200 μg per mouse (i.v.); 200 μg per mouse (s.c.)
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Administration:i.v. or s.c.; days 1, 4, and 7 (3 injections)
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Result:Significantly inhibited disease progression.
Reduced plasma levels of IL-6 and CD45+ leukocytes.
Increased IL-1β levels.
Reduced the infiltration of asialo-GM1+, F4/80+, CD4+, and CD8+ cells.
Lowered total anti-type II collagen IgG levels and anti-type II collagen IgG2a titers in vivo.
- BrdU Incorporation Assay
- Somatic Cell Culture
- CFSE Dye Dilution Proliferation Assay
- Dye-dilution cell tracking and proliferation staining
- CCK-8/WST-8 Cell Proliferation Assay
- Protocol for Cell Cycle
- Research Protocol for Inflammation-related Diseases
- Cell Counting-Based Growth Curve Assay
- Colony Formation (Clonogenic) Assay
- Cell Viability Determination by MTT Colorimetric Assay
- EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
- Collagen-Induced Arthritis
- Ki-67 Immunostaining Proliferation Assay
- PCNA Immunodetection Proliferation Assay
- Protocol for Cell Counting and Cell Density Analysis
- MTT Cell Proliferation Assay
Target
EDA-FN
Conjugated
Unconjugated
Application
ELISA, FACS, Functional assay
Chemical Information
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SMILES
[Dekavil]
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Synonyms
F8-IL10、PF-06687234
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dekavil Related Classifications
HY-P992552 Related Classifications
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