HM12
HM12 is a covalent inhibitor of L-/T-type calcium channels. HM12 can strongly inhibit the Cav1.2 (L-type) and Cav3.2 (T-type) calcium channels, and has selectivity for the N-type channels. HM12 produces an irreversible inhibition that persisted after washout. HM12 can be used to study diseases such as hypertension, pain, epilepsy, etc.
For research use only. We do not sell to patients.
- CAS No.: 2376051-91-9
- Formula: C25H27Br2NO6
- Molecular Weight:597.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Calcium Channel Isoforms
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Biological Activity
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Cav1.2 |
Cav3.2 |
HM12 (10 μM) exhibits > 90% inhibitory activity against the Cav3.2 calcium channel and > 60% inhibitory activity against the Cav1.2 calcium channel[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2376051-91-9
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Molecular Weight 597.29
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Formula C25H27Br2NO6
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SMILES
O=C(C1=C(C)NC2=C(C(C(C)(C)CC2)=O)C1C3=CC(Br)=CC(Br)=C3O)OCCOC(C(C)=C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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