1-Dodecanol
Based on 1 Customer Validation
1-Dodecanol is an endogenous metabolite.
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- Pureza: 99.99%
- No. CAS: 112-53-8
- Fòrmula: C12H26O
- Peso molecular:186.33
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Almacenamiento:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
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1-Dodecanol is a fatty alcohol with 12 carbon atoms. 1-Dodecanol can be used as industrial lubricants, surfactants, detergents, personal care products[1].
1-Dodecanol exhibits toxic to insects Rhodnius prolixus and Triatoma infestans that spread Chagas disease, LD50s for teneral R. prolixus, post-teneral R. prolixus, teneral T. infestans, and post-teneral T. infestans are 0.03, 18700, 9.1 and 32900 ng/i, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 112-53-8
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Appearance Liquid (Density: 0.833 g/cm3)
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Peso molecular 186.33
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Fòrmula C12H26O
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Color Colorless to light yellow
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SMILES
CCCCCCCCCCCCO
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvente y solubilidad
DMSO : 100 mg/mL (536.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (13.42 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (13.42 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (267 KB)
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SDS (597 KB)
- English - EN (597 KB)
- Français - FR (597 KB)
- Deutsch - DE (597 KB)
- Norwegian - NO (597 KB)
- Español - ES (597 KB)
- Swedish - SV (597 KB)
- Italian - IT (597 KB)
- Portuguese - PT (597 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Hsieh SC, et al., Production of 1-Dodecanol, 1-Tetradecanol, and 1,12-Dodecanediol through Whole-Cell Biotransformation in Escherichia coli. Appl Environ Microbiol. 2018 Jan 31;84(4):e01806-17. [Content Brief]
[2]. Cueto GM, et al., Biological effect of 1-dodecanol in teneral and post-teneral Rhodnius prolixus and Triatoma infestans (Hemiptera: Reduviidae). Mem Inst Oswaldo Cruz. 2005 Feb;100(1):59-61. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.3668 mL | 26.8341 mL | 53.6682 mL | 134.1706 mL |
| 5 mM | 1.0734 mL | 5.3668 mL | 10.7336 mL | 26.8341 mL | |
| 10 mM | 0.5367 mL | 2.6834 mL | 5.3668 mL | 13.4171 mL | |
| 15 mM | 0.3578 mL | 1.7889 mL | 3.5779 mL | 8.9447 mL | |
| 20 mM | 0.2683 mL | 1.3417 mL | 2.6834 mL | 6.7085 mL | |
| 25 mM | 0.2147 mL | 1.0734 mL | 2.1467 mL | 5.3668 mL | |
| 30 mM | 0.1789 mL | 0.8945 mL | 1.7889 mL | 4.4724 mL | |
| 40 mM | 0.1342 mL | 0.6709 mL | 1.3417 mL | 3.3543 mL | |
| 50 mM | 0.1073 mL | 0.5367 mL | 1.0734 mL | 2.6834 mL | |
| 60 mM | 0.0894 mL | 0.4472 mL | 0.8945 mL | 2.2362 mL | |
| 80 mM | 0.0671 mL | 0.3354 mL | 0.6709 mL | 1.6771 mL | |
| 100 mM | 0.0537 mL | 0.2683 mL | 0.5367 mL | 1.3417 mL |
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