5,7-Dihydroxytryptamine
5,7-Dihydroxytryptamine (5,7-DHP) is an autofluorescent (λex≈365 nm), selective neurotoxin and a transport substrate for MAO-A and 5-HT. 5,7-Dihydroxytryptamine can specifically target and damage central and peripheral 5-HTergic neurons, while affecting 5-HT-related pathways and neurotransmitter balance. 5,7-Dihydroxytryptamine can be used to establish 5-HTergic neuron injury models for studies on neural development, neurodegenerative diseases, as well as mechanisms related to platelet function and retinal neurons.
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- No. CAS: 31363-74-3
- Fòrmula: C10H12N2O2
- Peso molecular:192.21
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Chemical Information
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Actividad biológica
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MAO-A |
5,7-dihydroxytryptamine (25 μM; 60 min at 37°C) specifically labels serotonergic cells (but not dopaminergic cells) in 10-day-old primary mesencephalic cultures from 14-day-old Wistar rat foetuses[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
5,7-Dihydroxytryptamine (10 μg base; intracerebroventricular injection; single administration; 10 days prior to seizure induction) depletes 5-HT levels in the spinal cord of rats, but does not affect electrically induced spinal cord seizures in rats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 male mice (2 months old, 20-30 g)[1]
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Dosage:12.5, 25, 50.0 μg
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Administration:intracerebroventricularly; single dose
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Result:Depleted hippocampal norepinephrine by 68% and serotonin by 71% in mice not pretreated with MAO inhibitors.
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Animal Model:Sprague-Dawley (female, 180-220 g)[3]
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Dosage:10 µg of the base
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Administration:i.c.v.; single dose; 10 days before seizure induction
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Result:Reduced spinal cord 5-hydroxytryptamine levels to 0.21 µg/g ± 0.04; produced no changes in spinal cord norepinephrine content or electrically-induced spinal cord seizure parameters (duration of tonic flexion, tonic extension, or total seizure duration)
Chemical Information
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No. CAS 31363-74-3
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Peso molecular 192.21
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Fòrmula C10H12N2O2
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SMILES
NCCC1=CNC2=C(O)C=C(O)C=C12
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Synonyms
5,7-DHP
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Structure Classification
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Initial Source
rat
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Finnegan KT, et al. The amine-depleting effects of 5,7-dihydroxytryptamine (5,7-DHT) in C57BL/6 mice do not increase with age. Brain Res. 1989;496(1-2):251-256. [Content Brief]
[2]. Franke H, et al. 5,7-Dihydroxytryptamine--a selective marker of dopaminergic or serotonergic neurons?. Naunyn Schmiedebergs Arch Pharmacol. 2002;366(4):315-318. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
5,7-Dihydroxytryptamine Related Classifications
HY-N18471 Related Classifications
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- 5,7-Dihydroxytryptamine
- 31363-74-3
- 5,7-DHP
- Monoamine Oxidase
- 5-HT Receptor
- spinal cord 5-hydroxytryptamine
- Monoamine oxidase A (MAO A)
- C57BL/6 mice
- serotonin transporter
- hippocampal serotonin
- serotonergic neurone
- hippocampal norepinephrine
- noradrenergic neurone
- Wistar rat foetuses
- central nervous system 5-hydroxytryptaminergic neurone
- Inhibitor
- inhibitor
- inhibit