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BMS-754807

14 Cited Publications
Revisión del cliente

Based on 14 publication(s) in Google Scholar

BMS-754807 is a potent and reversible IGF-1R/IR inhibitor (IC50=1.8 and 1.7 nM, respectively; Ki=<2 nM for both). BMS-754807 also shows potent activities against Met, RON, TrkA, TrkB, AurA, and AurB with IC50 values of 6, 44, 7, 4, 9, and 25 nM, respectively.

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  • Pureza: 99.42%
  • No. CAS: 1001350-96-4
  • Fòrmula: C23H24FN9O
  • Peso molecular:461.49
  • Almacenamiento:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • BMS-754807 Chemical Structure
    BMS-754807 Chemical Structure
  • Experimental Validation Results for BMS-754807
  • Experimental Validation Results for BMS-754807
  • Experimental Validation Results for BMS-754807
  • Experimental Validation Results for BMS-754807
  • Experimental Validation Results for BMS-754807
No. CAS: 1001350-96-4
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Encuentre su distribuidor local Your local distributor: Hycultec GmbHHycultec
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Publications Citing Use of MedChemExpress (MCE) BMS-754807

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  • BMS-754807 Chemical Structure
    BMS-754807 Chemical Structure
    1/16
  • 1/16

    BMS-754807 purchased from MedChemExpress. Usage Cited in: Cell Rep. 2026 Feb 13;45(2):116971. [Abstract]

    Customer Validation
     Confocal images of the lateral head at 6 dpf comparing the cartilage and lymphatic phenotypes of lyve1b:dsRed (green) sox10:EGFP (magenta) larvae treated at 4 dpf with either DMSO (B), 0.61 μM (C), 1.25 μM (D), or 2.5 μM BMS-754807 (E).

  • 1/16

    BMS-754807 purchased from MedChemExpress. Usage Cited in: Elife. 2025 Mar 28:13:RP100002. [Abstract]

    Customer Validation
     Frequencies of CD45RO+CCR7+Th17 cells. Black represents CD4+ naive T cells treated with DMSO; gray represents CD4+ naive T cells co-cultured with NP-EV-treated macrophages; blue represents CD4+ naive T cells co-cultured with PE-EV-treated macrophages; red represents CD4+ naive T cells treated with BMS-754807 (10 μM; 3 days) before co-cultured with PE-EV-treated macrophages.

  • 1/16

    BMS-754807 purchased from MedChemExpress. Usage Cited in: mBio. 2023 Oct 31;14(5):e0211023. [Abstract]

    Customer Validation
     HEp-2 or HEK-293T cells were subjected to either simulated infection or RSV infection (MOI = 1) and cultured for a specified time with or without BMS-754807 (25 µM) or LY294002 (10 µM). Western blot analysis was performed on the expression of IR-α, IR-β, p-IRS1, IRS1, p-Akt, and Akt in HEp-2 cells at 0.25, 0.5, 1, 2, 6, 12, or 24 hours post-RSV infection.

  • 1/16

    BMS-754807 purchased from MedChemExpress. Usage Cited in: mBio. 2023 Oct 31;14(5):e0211023. [Abstract]

    Customer Validation
     HEp-2 or HEK-293T cells were subjected to either simulated infection or RSV infection (MOI = 1) and cultured for a specified time with or without BMS-754807 (25 µM) or LY294002 (10 µM). Immunolocalization of EGFP-p85α and mCherry-IRS1 in HEK293T cells was performed at 2, 6, 12, or 24 hours post-RSV infection.

  • 1/16

    BMS-754807 purchased from MedChemExpress. Usage Cited in: JCI Insight. 2022 Dec 8;7(23):e160555. [Abstract]

    Customer Validation
     Motion maps of DRG neuron axons treated with a carrier and an insulin receptor antagonist (BMS-754807, 300 or 500 nmol/L). Stimulation time was 60 minutes.

  • BMS-754807