Referencia número: HY-15066

CNQX

Name: CNQX
Brand: MedChemExpress
SKU: HY-15066
Price: 50.00 USD
Availability: InStock
Rating: 5 (25 reviews)

(Synonyms: FG9065)

25 Cited Publications

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Based on 25 publication(s) in Google Scholar

CNQX (FG9065) is a potent and competitive AMPA/kainate receptor antagonist with IC₅₀s of 0.3 μM and 1.5 μM, respectively. CNQX is a competitive non-NMDA receptor antagonist. CNQX blocks the expression of fear-potentiated startle in rats.

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Pureza : 99.38%
No. CAS: 115066-14-3
Fòrmula: C₉H₄N₄O₄
Peso molecular:232.15

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

CNQX Chemical Structure

No. CAS: 115066-14-3

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Use of MCE Products

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (25)
Solvente y solubilidad
- In Vitro
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

CNQX (FG9065) is a potent and competitive AMPA/kainate receptor antagonist with IC₅₀s of 0.3 μM and 1.5 μM, respectively. CNQX is a competitive non-NMDA receptor antagonist^[1]. CNQX blocks the expression of fear-potentiated startle in rats^[5].

IC₅₀ & Target

Kainate Receptor

Ver todos los productos específicos de isoformas iGluR :

In Vitro

CNQX (FG9065; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices^[2].
CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Wistar rats weighing 180-200 g^[4]
Dosage:

0.75, 1.5, and 3 mg/kg
Administration:

IP; 20 min before testing
Result:

Decreased the number of cocaine (IV; 0.25 mg/infusion) responses in a dose-dependent manner during the first 15-min cocaine-free interval

Related Protocols :

RNA extraction experimental

Chemical Information

No. CAS 115066-14-3
Appearance Solid
Peso molecular 232.15
Fòrmula C₉H₄N₄O₄
Color White to yellow
SMILES

O=C1C(NC2=CC([N+]([O-])=O)=C(C#N)C=C2N1)=O
Synonyms

FG9065
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (25)

All Bio/Physico-chemical Assay

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Journal Impact Factor

Cell

A skin-hypothalamus axis couples heat stress and metabolic dysfunction. [Abstract]

2026 Jun 11;189(12):3571-3588.e27. PMID: 42019490
Nat Neurosci

Emergence of consciousness from anesthesia through ubiquitin degradation of KCC2 in the ventral posteromedial nucleus of the thalamus. [Abstract]

2023 May;26(5):751-764. PMID: 36973513
Nat Commun

Novelty exploration-activated ensemble in the lateral hypothalamus confers analgesic and anxiolytic effects. [Abstract]

2026 May 19;17(1):4418. PMID: 42156381
Nat Commun

A ventral pallidum-locus coeruleus-lateral hypothalamus pathway modulates brain arousal in freely behaving and isoflurane-anesthetized male mice. [Abstract]

2025 May 16;16(1):4560. PMID: 40379709
Nat Commun

A non-canonical visual cortical-entorhinal pathway contributes to spatial navigation. [Abstract]

2024 May 15;15(1):4122. PMID: 38750027

CNQX purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 May 15;15(1):4122. [Abstract]

Light-evoked EPSCs in vCE L5a PCs were abolished after bath application of tetrodotoxin (TTX) but were then reintroduced following application of 4-Aminopyridine, indicating the monosynaptic nature of connections from V2 to vCE L5a. These restored responses were blocked by AMPA receptor antagonist CNQX.

CNQX purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 May 15;15(1):4122. [Abstract]

The light-evoked EPSCs were abolished by TTX and rescued by 4-AP, but severely attenuated by CNQX.
Adv Sci (Weinh)

Nigra-Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice. [Abstract]

2026 Jul;13(37):e19913. PMID: 41944312
Environ Sci Technol

Chronic Pb Exposure Induces Anxiety and Depression-like Behaviors in Mice via Excitatory Neuronal Hyperexcitability in Ventral Hippocampal Dentate Gyrus. [Abstract]

2023 Aug 22;57(33):12222-12233. PMID: 37559393
Cell Death Dis

Crosstalk of Synapsin1 palmitoylation and phosphorylation controls the dynamicity of synaptic vesicles in neurons. [Abstract]

2022 Sep 12;13(9):786. PMID: 36097267
J Neuroinflammation

Sleep deprivation induces anxiety-like behaviors through IL-6 driven astrocyte-GABAergic neuron crosstalk in the PAG-ACC circuit. [Abstract]

2026 May 22. PMID: 42174628
Acta Pharmacol Sin

Enhanced substance P-NK1R signaling in the parabrachial-parasubthalamic pathway promotes hyperalgesia and affective aversion in neuropathic pain. [Abstract]

2026 Aug 4. PMID: 42552466
Acta Biomater

Soft substrates promote direct chemical reprogramming of fibroblasts into neurons. [Abstract]

2022 Oct 15:152:255-272. PMID: 36041647
Cell Rep

Septo-subicular cholinergic circuit promotes seizure development via astrocytic inflammation. [Abstract]

2025 May 14;44(5):115712. PMID: 40372911
PLoS Biol

Supraspinal facilitation of painful stimuli by glutamatergic innervation from the retrosplenial to the anterior cingulate cortex. [Abstract]

2025 Jan 27;23(1):e3003011. PMID: 39869643

CNQX purchased from MedChemExpress. Usage Cited in: PLoS Biol. 2025 Jan 27;23(1):e3003011. [Abstract]

Sample traces of eEPSCs in the RSC-ACC projections with the perfusion of D-AP5 (50 μM), GYKI53655 (100 μM), and CNQX (20 μM) sequentially under the presence of picrotoxin (50 μM) (one-way RM ANOVA with Sidak multiple comparisons tests.

CNQX purchased from MedChemExpress. Usage Cited in: PLoS Biol. 2025 Jan 27;23(1):e3003011. [Abstract]

Sample amplitude curve of eEPSCs in the RSC-ACC projections with the perfusion of D-AP5 (50 μM), GYKI53655 (100 μM), and CNQX (20 μM) sequentially under the presence of picrotoxin (50 μM) (one-way RM ANOVA with Sidak multiple comparisons tests.

CNQX purchased from MedChemExpress. Usage Cited in: PLoS Biol. 2025 Jan 27;23(1):e3003011. [Abstract]

Averaged amplitude of eEPSCs in the RSC-ACC projections with the perfusion of D-AP5 (50 μM), GYKI53655 (100 μM), and CNQX (20 μM) sequentially under the presence of picrotoxin (50 μM) (one-way RM ANOVA with Sidak multiple comparisons tests.
Commun Biol

Environmental enrichment reverses ELS-induced visceral pain and depression through a prefrontal-limbic circuit involving CB1Rs. [Abstract]

2026 Apr 24;9(1):871. PMID: 42032059
Commun Biol

Neural mechanisms of the V2M-PrL pathway mediate blue light-induced spatial memory impairment. [Abstract]

2025 Dec 24;9(1):39. PMID: 41444415
Glia

Sustained Neuronal Stimulation Activates Paraventricular Thalamus Astrocytes for Chronicity of Neuropathic Pain in Mice. [Abstract]

2026 Aug;74(8):e70183. PMID: 42231639
J Cell Mol Med

The molecular mechanism underlying mitophagy-mediated hippocampal neuron apoptosis in diabetes-related depression. [Abstract]

2021 Aug;25(15):7342-7353. PMID: 34213839
Front Cell Neurosci

Pin1 Is Regulated by CaMKII Activation in Glutamate-Induced Retinal Neuronal Regulated Necrosis. [Abstract]

2019 Jun 25:13:276. PMID: 31293391
J Neurosci

Insula-amygdala and insula-thalamus pathways are involved in comorbid chronic pain and depression-like behavior in mice. [Abstract]

2024 Apr 10;44(15):e2062232024. PMID: 38453468
Nanotoxicology

Polystyrene nanoplastics promote tumor lung metastasis by inducing sodium overload in macrophages in an NMDAR-dependent way. [Abstract]

2026 May 19:1-18. PMID: 42154607
J Integr Neurosci

Endogenous Cannabinoid Receptors Modulate Plasticity at Immature Synapses. [Abstract]

2022 Jun 28;21(4):121. PMID: 35864772
Cereb Cortex

A circuit from lateral hypothalamic to dorsal hippocampal dentate gyrus modulates behavioral despair in mice. [Abstract]

2024 Oct 3;34(10):bhae399. PMID: 39367727
bioRxiv

2026 Aug 27.
SSRN

2025 Jun 18.
Biomed Pharmacother

Cordycepin suppresses glutamatergic and GABAergic synaptic transmission through activation of A1 adenosine receptor in rat hippocampal CA1 pyramidal neurons. [Abstract]

2022 Jan:145:112446. PMID: 34808556

Solvente y solubilidad

In Vitro:

DMSO : 20 mg/mL (86.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.3076 mL

21.5378 mL

43.0756 mL

5 mM

0.8615 mL

4.3076 mL

8.6151 mL

10 mM

0.4308 mL

2.1538 mL

4.3076 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (279 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. T Honoré, et al. Quinoxalinediones: Potent Competitive non-NMDA Glutamate Receptor Antagonists. Science. 1988 Aug 5;241(4866):701-3. [Content Brief]

[2]. Neuman RS, et al. Blockade of excitatory synaptic transmission by 6-cyano-7-nitroquinoxaline-2,3-dione(CNQX) in the hippocampus in vitro. Neurosci Lett. 1988 Sep 23;92(1):64-8. [Content Brief]

[3]. Alford S, et al. CNQX and DNQX block non-NMDA synaptic transmission but not NMDA-evoked locomotion in lamprey spinal cord. Brain Res. 1990 Jan 8;506(2):297-302. [Content Brief]

[4]. Pia Bäckström, et al. Attenuation of Cocaine-Seeking Behaviour by the AMPA/kainate Receptor Antagonist CNQX in Rats. Psychopharmacology (Berl). 2003 Feb;166(1):69-76. [Content Brief]

[5]. Kim M, et al. Infusion of the non-NMDA receptor antagonist CNQX into the amygdala blocks the expression of fear-potentiated startle. Behav Neural Biol. 1993 Jan;59(1):5-8. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.3076 mL	21.5378 mL	43.0756 mL	107.6890 mL
	5 mM	0.8615 mL	4.3076 mL	8.6151 mL	21.5378 mL
	10 mM	0.4308 mL	2.1538 mL	4.3076 mL	10.7689 mL
	15 mM	0.2872 mL	1.4359 mL	2.8717 mL	7.1793 mL
	20 mM	0.2154 mL	1.0769 mL	2.1538 mL	5.3844 mL
	25 mM	0.1723 mL	0.8615 mL	1.7230 mL	4.3076 mL
	30 mM	0.1436 mL	0.7179 mL	1.4359 mL	3.5896 mL
	40 mM	0.1077 mL	0.5384 mL	1.0769 mL	2.6922 mL
	50 mM	0.0862 mL	0.4308 mL	0.8615 mL	2.1538 mL
	60 mM	0.0718 mL	0.3590 mL	0.7179 mL	1.7948 mL
	80 mM	0.0538 mL	0.2692 mL	0.5384 mL	1.3461 mL

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CNQX

25 Cited Publications

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CNQX

Publications Citing Use of MedChemExpress (MCE) CNQX

Ver todos los productos específicos de isoformas iGluR