Referencia número: HY-112820

Chlorantraniliprole

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

Chlorantraniliprole is an insecticide that potently and selectively activates insect ryanodine receptor, with EC₅₀s of 40 nM and 50 nM for Drosophila melanogaster and H. virescens ryanodine receptor, and ～300-fold more potent than that in the mouse myoblast cell line, C2C12 (EC₅₀, 14 μM).

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Pureza: 98.05%
No. CAS: 500008-45-7
Fòrmula: C₁₈H₁₄BrCl₂N₅O₂
Peso molecular:483.15

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Chlorantraniliprole Chemical Structure

No. CAS: 500008-45-7

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Solvente y solubilidad
- In Vitro
- In Vivo
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target

EC50: 40 nM (Drosophila melanogaster Ryanodine receptor), 50 nM (H. virescens Ryanodine receptor), 14 μM (Ryanodine receptor, in C2C12 cells)

Cellular Effect

Cell Line	Type	Value	Description	References
C2C12	EC₅₀	14 μM Compound: rynaxypyr	Activation of ryanodine receptor in mouse C2C12 cells assessed as induction of calcium mobilization Activation of ryanodine receptor in mouse C2C12 cells assessed as induction of calcium mobilization	[PMID: 17884492]
C2C12	EC₅₀	14 μM Compound: 5	Activation of ryanodine receptor 1 in mouse C2C12 cells assessed as induction of calcium mobilization Activation of ryanodine receptor 1 in mouse C2C12 cells assessed as induction of calcium mobilization	[PMID: 19186058]
IMR-32	EC₅₀	>100 μM Compound: rynaxypyr	Activation of ryanodine receptor in human IMR32 cells assessed as induction of calcium mobilization Activation of ryanodine receptor in human IMR32 cells assessed as induction of calcium mobilization	[PMID: 17884492]
IMR-32	EC₅₀	>100 μM Compound: 5	Activation of ryanodine receptor in human IMR32 cells assessed as induction of calcium mobilization Activation of ryanodine receptor in human IMR32 cells assessed as induction of calcium mobilization	[PMID: 19186058]
PC-12	EC₅₀	>100 μM Compound: rynaxypyr	Activation of ryanodine receptor in rat PC12 cells assessed as induction of calcium mobilization Activation of ryanodine receptor in rat PC12 cells assessed as induction of calcium mobilization	[PMID: 17884492]
PC-12	EC₅₀	>100 μM Compound: 5	Activation of ryanodine receptor 2 in rat PC12 cells assessed as induction of calcium mobilization Activation of ryanodine receptor 2 in rat PC12 cells assessed as induction of calcium mobilization	[PMID: 19186058]
Sf9	EC₅₀	0.04 μM Compound: rynaxypyr	Activation of Drosophila melanogaster ryanodine receptor in Sf9 cells assessed as induction of calcium mobilization Activation of Drosophila melanogaster ryanodine receptor in Sf9 cells assessed as induction of calcium mobilization	[PMID: 17884492]
Sf9	EC₅₀	0.05 μM Compound: rynaxypyr	Activation of Heliothis virescens recombinant ryanodine receptor expressed in Sf9 cells assessed as induction of calcium mobilization Activation of Heliothis virescens recombinant ryanodine receptor expressed in Sf9 cells assessed as induction of calcium mobilization	[PMID: 17884492]
Sf9	EC₅₀	52 nM Compound: D3	Activation of Heliothis virescens recombinant ryanodine receptor expressed in Sf9 cells assessed as induction of calcium mobilization Activation of Heliothis virescens recombinant ryanodine receptor expressed in Sf9 cells assessed as induction of calcium mobilization	[PMID: 17884492]

In Vitro

Chlorantraniliprole is an insecticide that potently and selectively activates insect ryanodine receptor. Chlorantraniliprole actions by release of intracellular Ca²⁺ stores mediated by the ryanodine receptor. Chlorantraniliprole is ～300-fold less potent against ryanodine receptor (RyRs) in the mouse myoblast cell line, C2C12 (EC₅₀, 14 μM), than in insect RyRs from Drosophila melanogaster and H. virescens (EC₅₀, 40 nM, 50 nM), and shows little selectivity at the rat cell line RyR2 (EC₅₀, >100 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Chlorantraniliprole has low acute mammalian toxicity with an acute oral LD₅₀ of >5000 mg/kg in rats, and little to no toxicity in 90-day studies, at dosing as high as 1500 mg/kg/day^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 500008-45-7
Appearance Solid
Peso molecular 483.15
Fòrmula C₁₈H₁₄BrCl₂N₅O₂
Color White to off-white
SMILES

O=C(C1=CC(Br)=NN1C2=NC=CC=C2Cl)NC3=C(C(NC)=O)C=C(Cl)C=C3C
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (2)

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Anal Chem

Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]

2025 Jun 3;97(21):11099-11109. PMID: 40401576
J Agric Food Chem

Molecular Characterization of Spodoptera frugiperda Heme Oxygenase and Its Involvement in Susceptibility to Chlorantraniliprole. [Abstract]

2023 Feb 8;71(5):2313-2321. PMID: 36705998

Solvente y solubilidad

In Vitro:

DMSO : ≥ 62.5 mg/mL (129.36 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.0698 mL

10.3488 mL

20.6975 mL

5 mM

0.4140 mL

2.0698 mL

4.1395 mL

10 mM

0.2070 mL

1.0349 mL

2.0698 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (4.31 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: 2.08 mg/mL (4.31 mM); Clear solution; Need warming

This protocol yields a clear solution of 2.08 mg/mL. If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (280 KB)
SDS (596 KB)
- English - EN (596 KB)
- Français - FR (596 KB)
- Deutsch - DE (596 KB)
- Norwegian - NO (596 KB)
- Español - ES (596 KB)
- Swedish - SV (596 KB)
- Italian - IT (596 KB)
- Korean - KR (596 KB)
- Portuguese - PT (596 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. George P.Lahm, et al. Rynaxypyr: A new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator. Bioorganic & Medicinal Chemistry Letters. 2007 Nov 15;17(22):6274-6279.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.0698 mL	10.3488 mL	20.6975 mL	51.7438 mL
	5 mM	0.4140 mL	2.0698 mL	4.1395 mL	10.3488 mL
	10 mM	0.2070 mL	1.0349 mL	2.0698 mL	5.1744 mL
	15 mM	0.1380 mL	0.6899 mL	1.3798 mL	3.4496 mL
	20 mM	0.1035 mL	0.5174 mL	1.0349 mL	2.5872 mL
	25 mM	0.0828 mL	0.4140 mL	0.8279 mL	2.0698 mL
	30 mM	0.0690 mL	0.3450 mL	0.6899 mL	1.7248 mL
	40 mM	0.0517 mL	0.2587 mL	0.5174 mL	1.2936 mL
	50 mM	0.0414 mL	0.2070 mL	0.4140 mL	1.0349 mL
	60 mM	0.0345 mL	0.1725 mL	0.3450 mL	0.8624 mL
	80 mM	0.0259 mL	0.1294 mL	0.2587 mL	0.6468 mL
	100 mM	0.0207 mL	0.1035 mL	0.2070 mL	0.5174 mL

Keywords

Chlorantraniliprole

2 Cited Publications

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Chlorantraniliprole

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Publications Citing Use of MedChemExpress (MCE) Chlorantraniliprole

Actividad biológica

Chemical Information

Publications (2)

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

Chlorantraniliprole

Anti-Infection Compound Library

Targeted Diversity Library

Heterocyclic Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Pesticide Compound Library

High-Throughput Bioactive Compound Library

Environmental Pollutant Compound Library

Publications Citing Use of MedChemExpress (MCE) Chlorantraniliprole

Actividad biológica

Chemical Information

Publications (2)

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

Chlorantraniliprole Related Classifications

HY-112820 Related Classifications