Oleamide
Based on 1 publication(s) in Google Scholar
Oleamide is an endogenous fatty acid amide which can be synthesized de novo in the mammalian nervous system, and has been detected in human plasma.
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- Pureza: 99.96%
- No. CAS: 301-02-0
- Fòrmula: C18H35NO
- Peso molecular:281.48
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
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Publications Citing Use of MedChemExpress (MCE) Oleamide
MoreVer todos los productos específicos de isoformas Endogenous Metabolite
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Actividad biológica
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Human Endogenous Metabolite |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Oocyte | EC50 |
15 μM
Compound: 8
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Inhibitory activity against Gamma-aminobutyric acid A (GABA-A) receptor from rat cultured cortical neuron RNA expressed in Xenopus oocytes
Inhibitory activity against Gamma-aminobutyric acid A (GABA-A) receptor from rat cultured cortical neuron RNA expressed in Xenopus oocytes
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[PMID: 10780899] |
Oleamide accumulates in the cerebrospinal fluid (CSF) of rats after six hours of sleep deprivation and induces sleep in naive rats and mice. Inhibition of the primary catabolic enzyme of oleamide (fatty acid amide hydrolase) by trifluoromethyl-octadecenone reduces sleep latency and increases total sleep time when given centrally to rats and peripherally to mice[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 301-02-0
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Appearance Solid
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Peso molecular 281.48
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Fòrmula C18H35NO
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Color White to off-white
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SMILES
CCCCCCCC/C=C\CCCCCCCC(N)=O
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Nat Commun
2024 Sep 19;15(1):8221. PMID: 39300135
Solvente y solubilidad
Ethanol : ≥ 100 mg/mL (355.27 mM)
DMSO : 100 mg/mL (355.27 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (8.88 mM); Clear solution; Need ultrasonic
This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% EtOH 90% Corn Oil
Solubility: 2.5 mg/mL (8.88 mM); Clear solution; Need ultrasonic
This protocol yields a clear solution of 2.5 mg/mL. If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (266 KB)
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SDS (396 KB)
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- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / DMSO | 1 mM | 3.5527 mL | 17.7633 mL | 35.5265 mL | 88.8163 mL |
| 5 mM | 0.7105 mL | 3.5527 mL | 7.1053 mL | 17.7633 mL | |
| 10 mM | 0.3553 mL | 1.7763 mL | 3.5527 mL | 8.8816 mL | |
| 15 mM | 0.2368 mL | 1.1842 mL | 2.3684 mL | 5.9211 mL | |
| 20 mM | 0.1776 mL | 0.8882 mL | 1.7763 mL | 4.4408 mL | |
| 25 mM | 0.1421 mL | 0.7105 mL | 1.4211 mL | 3.5527 mL | |
| 30 mM | 0.1184 mL | 0.5921 mL | 1.1842 mL | 2.9605 mL | |
| 40 mM | 0.0888 mL | 0.4441 mL | 0.8882 mL | 2.2204 mL | |
| 50 mM | 0.0711 mL | 0.3553 mL | 0.7105 mL | 1.7763 mL | |
| 60 mM | 0.0592 mL | 0.2961 mL | 0.5921 mL | 1.4803 mL | |
| 80 mM | 0.0444 mL | 0.2220 mL | 0.4441 mL | 1.1102 mL | |
| 100 mM | 0.0355 mL | 0.1776 mL | 0.3553 mL | 0.8882 mL |
Oleamide Related Classifications
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