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Silvestrol

(Synonyms: (-)-Silvestrol)
53 Cited Publications
Revisión del cliente

Based on 53 publication(s) in Google Scholar

Silvestrol is a eukaryotic translation initiation factor 4A (eIF4A) inhibitor isolated from Agave americana Linn.. Silvestrol induces autophagy and caspase-mediated apoptosis.

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  • Pureza: 99.96%
  • No. CAS: 697235-38-4
  • Fòrmula: C34H38O13
  • Peso molecular:654.66
  • Almacenamiento:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Silvestrol Chemical Structure
    Silvestrol Chemical Structure
  • Experimental Validation Results for Silvestrol
  • Experimental Validation Results for Silvestrol
  • Experimental Validation Results for Silvestrol
  • Experimental Validation Results for Silvestrol
  • Experimental Validation Results for Silvestrol
  • Experimental Validation Results for Silvestrol
  • Experimental Validation Results for Silvestrol
  • Experimental Validation Results for Silvestrol
  • Experimental Validation Results for Silvestrol
  • Experimental Validation Results for Silvestrol
  • Experimental Validation Results for Silvestrol
  • Experimental Validation Results for Silvestrol
  • Experimental Validation Results for Silvestrol
  • Experimental Validation Results for Silvestrol
  • Experimental Validation Results for Silvestrol
  • Experimental Validation Results for Silvestrol
  • Experimental Validation Results for Silvestrol
No. CAS: 697235-38-4
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Encuentre su distribuidor local Your local distributor: Hycultec GmbHHycultec
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  • Silvestrol Chemical Structure
    Silvestrol Chemical Structure
    1/16
  • 1/16

    Silvestrol purchased from MedChemExpress. Usage Cited in: Clin Cancer Res. 2018 Sep 1;24(17):4256-4270. [Abstract]

    Customer Validation
     Western blot showing protein expression of translationally regulated genes in DLBCL cells treated with DMSO (D), 50 nM Silvestrol (S) or 5 μM elatol for 16h. Representative images, n=3.

  • 1/16

    Silvestrol purchased from MedChemExpress. Usage Cited in: Antiviral Res. 2018 Feb:150:123-129. [Abstract]

    Customer Validation
     Huh-7 cells are infected with HCoV-229E at an MOI of 3 and treated with the indicated concentrations of silvestrol. Cell lysates are prepared at 12 h p.i. and 48 h p.i. as indicated and the accumulation of viral N and nsp8 proteins is determined by Western blot analysis.

  • 1/16

    Silvestrol purchased from MedChemExpress. Usage Cited in: Antiviral Res. 2018 Feb:150:123-129. [Abstract]

    Customer Validation
     MRC-5 cells are infected with HCoV-229E at an MOI of 3 and treated with the indicated concentrations of silvestrol. Cell lysates are prepared at 12 h p.i. and 48 h p.i. as indicated and the accumulation of viral N and nsp8 proteins is determined by Western blot analysis.

  • 1/16

    Silvestrol purchased from MedChemExpress. Usage Cited in: Antiviral Res. 2018 Sep:157:151-158. [Abstract]

    Customer Validation
     Immunofluorescence staining of HEVp6 transfected Huh7.5 cells treated with Silvestrol (low concentration: 2.5 nM and medium concentration: 10 nM), ICN-1229 or DMSO 4 h after transfection for 42 h.

  • 1/16

    Silvestrol purchased from MedChemExpress. Usage Cited in: Viruses. 2018 Mar 27;10(4):149. [Abstract]

    Customer Validation
     A549 cells are infected with ZIKV U and treated with the indicated amount of Silvestrol. Cell lysates of the indicated time points are analyzed by Western blot with specific antibodies against NS1 and β-actin.

  • 1/16

    Silvestrol purchased from MedChemExpress. Usage Cited in: Viruses. 2018 Mar 27;10(4):149. [Abstract]

    Customer Validation
     A549 cells are infected with ZIKV FP and treated with the indicated amount of Silvestrol. Cell lysates of the indicated time points are analyzed by Western blot with specific antibodies against NS1 and β-actin.

  • 1/16

    Silvestrol purchased from MedChemExpress. Usage Cited in: Viruses. 2018 Jun 2;10(6):301. [Abstract]

    Customer Validation
     Representative Western Blot of cellular lysates derived from cells treated with either 2 nM or 50 nM Silvestrol. DMSO treatment serves as control.

  • 1/16

    Silvestrol purchased from MedChemExpress. Usage Cited in: Viruses. 2018 Oct 30;10(11):592. [Abstract]

    Customer Validation
     Infection of 293T cells with CHIKV-mCherry in the presence of 50 nM silvestrol. Western blot analysis of cell lysates prepared from 293T cells infected with CHIKV-mCherry.

  • 1/16

    Silvestrol purchased from MedChemExpress. Usage Cited in: University of Miami. 2018 Jul.

    Customer Validation
     Western blot analysis of translationally regulates protein expression after 16h treatment.

  • 1/16

    Silvestrol purchased from MedChemExpress. Usage Cited in: Oncogene. 2017 Nov 9;36(45):6225-6234. [Abstract]

    Customer Validation
     Sin1 protein level decreases in cells treated with silvestrol. HT29-P or HCT116 cells were treated with indicated concentration of Silvestrol for 24 h. The ratio of Sin1/GAPDH and Snail/GAPDH in DMSO (0 nM Silvestrol) treated cells is designated as 1.0.

  • 1/16

    Silvestrol purchased from MedChemExpress. Usage Cited in: Antiviral Res. 2017 Jan:137:76-81. [Abstract]

    Customer Validation
     PIM1 levels are strongly decreased (to almost below detection limits) in the presence of 10 nM Silvestrol. This inhibitory effect persists for at least 5 days using a single dose of Silvestrol, without affecting cellular β-Actin levels.

  • 1/16

    Silvestrol purchased from MedChemExpress. Usage Cited in: Viruses. 2017 Dec 18;9(12):388. [Abstract]

    Customer Validation
     Western blotting analysis of A549 cell lysates obtained at the indicated times post-infection with the PR8 strain of IAV and treated with 320 nM silvestrol (Sil.) or 20 nM pateamine A (PatA) at 4 hpi or the equivalent time after mock infection.

  • 1/16

    Silvestrol purchased from MedChemExpress. Usage Cited in: EMBO J. 2016 Jun 1;35(11):1186-203. [Abstract]

    Customer Validation
     The inhibitory effect of Silvestrol in translation is observed despite a two to five fold increase of reporter mRNA levels in HEK293 cells

  • 1/16

    Silvestrol purchased from MedChemExpress. Usage Cited in: Cancer Discov. 2015 Jul;5(7):768-781. [Abstract]

    Customer Validation
     Immunoblots of four colorectal cell lines upon treatment with increasing concentration of Silvestrol or solvent control (n=2).

  • 1/16

    Silvestrol purchased from MedChemExpress. Usage Cited in: Nature. 2014 Sep 4;513(7516):65-70. [Abstract]

    Customer Validation
     Immunoblots of lysates from human T-ALL lines treated with Silvestrol (25 nM, 24h) and probed as indicated.

  • 1/16

    Silvestrol purchased from MedChemExpress. Usage Cited in: Blood. 2014 Dec 11;124(25):3758-67. [Abstract]

    Customer Validation
     (A)Protein lysates from human splenic B cells are harvested 24 hours after treatment with Isotype + Vehicle, Isotype + 10 nM Silvestrol, anti-BCR + Vehicle, or anti-BCR + 10 nM Silvestrol and incubated with m7GTP Sepharose beads overnight at 4°C. Western blot analysis is used to observe eIF4A and eIF4E binding to m7GTP. Data are representative of 3e independent experiments. (B) Twenty-four hours after treatment, cells are incubated with 1 mCi L-[35S]methionine and L-[35S]cy

  • 1/16

    Silvestrol purchased from MedChemExpress. Usage Cited in: University of Maryland. 2014.

    Customer Validation
     IgG positive B-cells display more significant modulation of CARD11 protein levels upon BCR activation and treatment with Silvestrol.

  • Silvestrol