AB12-82
AB12-82 is a selective dopamine receptor agonist with a Ki value of 1.88 nM for human D3R. AB12-82 achieves subtype-selective D3R activation by enhancing interactions with the D3R H291·32 residue. AB12-82 can be used in the research of nervous system-related diseases.
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- Fòrmula: C26H33N5O3
- Peso molecular:463.57
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Ver todos los productos específicos de isoformas Dopamine Receptor
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Actividad biológica
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Human D3 Receptor 1.88 nM (Ki) |
Human D2 Receptor 41 nM (Ki) |
AB12-82 (compound 6d) binds to hD3R with a Ki value of 1.88 nM, and exhibits a 21.8-fold binding selectivity over hD2L R (it binds to hD2R with a Ki value of 41 nM)[1].
AB12-82 acts as a partial agonist of hD3R, with a pEC50 of 11.76 (0.00174 nM) and an efficacy of 84.57%. Its potency for hD3R is >575000-fold more selective than that for hD2R[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Peso molecular 463.57
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Fòrmula C26H33N5O3
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SMILES
NC1=CC=C(C=N1)[C@H]2CN([C@H](CO2)C)CC3C(CCNC(C4=CC5=C(N4)C=CC(OC)=C5)=O)C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AB12-82 Related Classifications
HY-184590 Related Classifications
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