AB13-46A
AB13-46A is a selective dopamine receptor agonist, with a Ki value of 0.505 nM against human D3R. AB13-46A can be used for research on nervous system-related diseases.
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- Fòrmula: C26H33N5O3
- Peso molecular:463.57
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Ver todos los productos específicos de isoformas Dopamine Receptor
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
Human D3 Receptor 0.505 nM (Ki) |
Human D2 Receptor 104 nM (Ki) |
In Vitro
AB13-46A (compound 9) is a full agonist with sub-nanomolar potency at the human dopamine D3 receptor (hD3R), and exhibits a potency selectivity of up to 6300-fold over the human dopamine D2 receptor (hD2R)[1].
AB13-46A (48 h) exhibits reduced potency when the H291.32 residue of the human dopamine D3 receptor (hD3R) is mutated, indicating that this residue contributes to optimal agonist-induced receptor activation[1].
AB13-46A (10-50 μM; 30 min) binds to the human dopamine D3 receptor (hD3R) in a two-site mode[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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Peso molecular 463.57
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Fòrmula C26H33N5O3
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SMILES
NC1=CC=C(C=N1)[C@H]2CN([C@H](CO2)C)C[C@@H]3[C@@H](CCNC(C4=CC5=C(N4)C=C(C=C5)OC)=O)C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AB13-46A Related Classifications
HY-184589 Related Classifications
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