AC-099
AC-099 (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM). AC-099 attenuates spinal nerve ligation-induced hypersensitivity in rats.
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- No. CAS: 849459-88-7
- Fòrmula: C9H8ClF3N4
- Peso molecular:264.63
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| COS-1 | EC50 |
1189 nM
Compound: AC-099
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Agonist activity at human NPFF2 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting
Agonist activity at human NPFF2 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting
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[PMID: 22708927] |
| COS-1 | EC50 |
2370 nM
Compound: AC-099
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Agonist activity at human NPFF1 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting
Agonist activity at human NPFF1 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting
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[PMID: 22708927] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 849459-88-7
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Peso molecular 264.63
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Fòrmula C9H8ClF3N4
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SMILES
FC(C1=CC(/C=N/NC(N)=N)=CC=C1Cl)(F)F
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Findeisen M, et al. Selective mode of action of guanidine-containing non-peptides at human NPFF receptors. J Med Chem. 2012 Jul 12;55(13):6124-36. [Content Brief]
[2]. Gaubert G, et al. Discovery of selective nonpeptidergic neuropeptide FF2 receptor agonists. J Med Chem. 2009 Nov 12;52(21):6511-4. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AC-099 Related Classifications
HY-154829 Related Classifications
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