Ac32Az19
Based on 1 publication(s) in Google Scholar
Ac32Az19 is a potent, nontoxic, and highly selective BCRP inhibitor with an EC50 value of 13 nM in the BCRP-overexpressed HEK293/R2 cells.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.12%
- No. CAS: 2760674-72-2
- Fòrmula: C37H33N3O6
- Peso molecular:615.67
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Almacenamiento:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Ac32Az19
More
Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L929 | IC50 |
>100 μM
Compound: Ac32Az19
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Cytotoxicity against mouse L929 cells assessed as reduction in cell viability
Cytotoxicity against mouse L929 cells assessed as reduction in cell viability
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[PMID: 34606270] |
Chemical Information
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No. CAS 2760674-72-2
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Appearance Solid
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Peso molecular 615.67
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Fòrmula C37H33N3O6
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Color Off-white to light yellow
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SMILES
O=C1C(OCC2=CC(C(OC)=O)=CC=C2)=C(OC3=CC=CC=C31)C4=CC=C(C=C4)OCCCCC5=CN(N=N5)CC6=CC=CC=C6
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Cell Metab
ABCG2 is an itaconate exporter that limits antibacterial innate immunity by alleviating TFEB-dependent lysosomal biogenesis. [Abstract]2024 Mar 5;36(3):498-510.e11. PMID: 38181789
Solvente y solubilidad
DMSO : 60 mg/mL (97.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6242 mL | 8.1212 mL | 16.2425 mL | 40.6062 mL |
| 5 mM | 0.3248 mL | 1.6242 mL | 3.2485 mL | 8.1212 mL | |
| 10 mM | 0.1624 mL | 0.8121 mL | 1.6242 mL | 4.0606 mL | |
| 15 mM | 0.1083 mL | 0.5414 mL | 1.0828 mL | 2.7071 mL | |
| 20 mM | 0.0812 mL | 0.4061 mL | 0.8121 mL | 2.0303 mL | |
| 25 mM | 0.0650 mL | 0.3248 mL | 0.6497 mL | 1.6242 mL | |
| 30 mM | 0.0541 mL | 0.2707 mL | 0.5414 mL | 1.3535 mL | |
| 40 mM | 0.0406 mL | 0.2030 mL | 0.4061 mL | 1.0152 mL | |
| 50 mM | 0.0325 mL | 0.1624 mL | 0.3248 mL | 0.8121 mL | |
| 60 mM | 0.0271 mL | 0.1354 mL | 0.2707 mL | 0.6768 mL | |
| 80 mM | 0.0203 mL | 0.1015 mL | 0.2030 mL | 0.5076 mL |
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