Acedoben
Based on 1 Customer Validation
Acedoben is a biochemical reagent. Acedoben can form a rapidly self-assembled coordination complex with iron ions. The Fe-Ace coordination complex not only serves as a carrier for tumor antigens, but also enhances antigen-specific anti-tumor immunity due to its inherent adjuvant properties.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.68%
- No. CAS: 556-08-1
- Fòrmula: C9H9NO3
- Peso molecular:179.17
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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HY-B1250R
Acedoben (Standard)
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HY-B1258
4-(Aminomethyl)benzoic acid
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HY-W040265
Fenamic acid
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HY-W206016
3-Aminosalicylic acid
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HY-W001171
3-Hydroxyanthranilic acid
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HY-W001131
2-Amino-6-fluorobenzoic acid
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HY-W001171R
3-Hydroxyanthranilic acid (Standard)
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HY-B1258R
4-(Aminomethyl)benzoic acid (Standard)
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HY-Y0124
NSC 16590
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HY-W004675
2-Aminoterephthalic acid
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HY-W010224
3-Amino-4-hydroxybenzoic acid
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HY-W040265R
Fenamic acid (Standard)
Actividad biológica
Acedoben (AcPABA) exhibits a lambda maximum of 214 nm and a molar extinction coefficient of 1.67×106 M-1·cm-1 in aqueous solution[1].
Acedoben has carboxylic acid C=O and amidic C=O IR absorption peaks at 1672 cm−1 and 1608 cm−1, respectively, when analyzed as a KBr pellet[1].
Acedoben has a carboxylic acid pKa of 4.60 in 1:1 DMF:water solution, while its amidic hydrogen pKa is too high to measure via NaOH titration[1].
Acedoben has a Kow of 1.22 at pH 2.0 and a logD of -1.10 at pH 7.4, demonstrating lower lipophilicity than its trifluoroacetamido derivative under both conditions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 556-08-1
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Appearance Solid
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Peso molecular 179.17
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Fòrmula C9H9NO3
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Color White to off-white
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SMILES
O=C(O)C1=CC=C(NC(C)=O)C=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 100 mg/mL (558.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (13.95 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (13.95 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (303 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.5813 mL | 27.9065 mL | 55.8129 mL | 139.5323 mL |
| 5 mM | 1.1163 mL | 5.5813 mL | 11.1626 mL | 27.9065 mL | |
| 10 mM | 0.5581 mL | 2.7906 mL | 5.5813 mL | 13.9532 mL | |
| 15 mM | 0.3721 mL | 1.8604 mL | 3.7209 mL | 9.3022 mL | |
| 20 mM | 0.2791 mL | 1.3953 mL | 2.7906 mL | 6.9766 mL | |
| 25 mM | 0.2233 mL | 1.1163 mL | 2.2325 mL | 5.5813 mL | |
| 30 mM | 0.1860 mL | 0.9302 mL | 1.8604 mL | 4.6511 mL | |
| 40 mM | 0.1395 mL | 0.6977 mL | 1.3953 mL | 3.4883 mL | |
| 50 mM | 0.1116 mL | 0.5581 mL | 1.1163 mL | 2.7906 mL | |
| 60 mM | 0.0930 mL | 0.4651 mL | 0.9302 mL | 2.3255 mL | |
| 80 mM | 0.0698 mL | 0.3488 mL | 0.6977 mL | 1.7442 mL | |
| 100 mM | 0.0558 mL | 0.2791 mL | 0.5581 mL | 1.3953 mL |
Acedoben Related Classifications
HY-B1250 Related Classifications
Powered by Bioz
- Acedoben
- 556-08-1
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