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Referencia número: HY-136557

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AFM32a

(Synonyms: PAD2-IN-1)

2 Cited Publications

Revisión del cliente

Based on 2 publication(s) in Google Scholar

AFM32a (PAD2-IN-1), a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. AFM32a shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold).

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No. CAS: 2095109-82-1
Fòrmula: C₂₅H₂₉FN₆O₃
Peso molecular:480.53

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

AFM32a Chemical Structure

No. CAS: 2095109-82-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Actividad biológica

Descripciòn

IC₅₀ & Target

Protein Arginine Deiminase 2 (PAD2)^[1]

In Vitro

In the target engagement assay, the EC ₅₀ of AFM32a (compound 32a) is 8.3 μM in HEK293T/PAD2 cells, the enhanced potency of AFM32a overcomes its relatively poor ability to enter cells^[1].
AFM32a (compound 32a; 1-25 μM) treatment strongly inhibits histone H3 citrullination with an EC ₅₀ of 2.7 μM in HEK293T/PAD2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 2095109-82-1
Peso molecular 480.53
Fòrmula C₂₅H₂₉FN₆O₃
SMILES

O=C(C1=CC=CC(CN2)=C1C2=O)N[C@H](C3=NC4=C(OCC)C=CC=C4N3C)CCCNC(CF)=N
Synonyms

PAD2-IN-1
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Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Adv Sci (Weinh)

Succinate Dehydrogenase Subunit A (SDHA) Mediated Microglia Extracellular Traps Formation Participating in Cerebral Ischemic Reperfusion Injury. [Abstract]

2025 Aug 20:e11873. PMID: 40832885
Front Immunol

Interaction Between Macrophage Extracellular Traps and Colon Cancer Cells Promotes Colon Cancer Invasion and Correlates With Unfavorable Prognosis. [Abstract]

2021 Dec 1:12:779325. PMID: 34925357

Pureza y Documentación

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Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Aaron Muth, et al. Development of a Selective Inhibitor of Protein Arginine Deiminase 2. J Med Chem. 2017 Apr 13;60(7):3198-3211. [Content Brief]

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AFM32a

2 Cited Publications

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AFM32a

Publications Citing Use of MedChemExpress (MCE) AFM32a

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AFM32a Related Classifications

HY-136557 Related Classifications