Anticancer agent 160
Anticancer agent 160 (Compound 6) is a natural product derived from Parthenium hysterophorus. Anticancer agent 160 is cytotoxic to HCT-116 cells, IC50=5.0 μM.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 2983122-03-6
- Fòrmula: C28H29NO6
- Peso molecular:475.53
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
|
Caspase 3 23.4 nM (EC50) |
M109S (0.1-10000 nM, 24-48 h) can inhibit apoptosis induced by Bax as well as Bak[1].
M109S (0-10μM, 4 h) M109S suppresses Staurosporine (HY-15141 STS)-induced apoptosis in MEFs [1].
M109S (0-10μM, 24 h) inhibits Etoposide(HY-13629)-induced apoptosis in Neuro2a cells[1].
M109S (500 nM, 24 h) inhibits Obatoclax(HY-10969A)-induced apoptosis in ARPE19 cells[1].
M109S (500 nM, 48 h) suppresses the conformation change (N-terminal exposure) [1].
M109S (500 nM, 48 h) suppresses the mitochondrial translocation of Bax[1].
M109S(1.0 μM, 4 h) decreases mitochondrial oxygen consumption and reactive oxygen species, whereas M109S(0.1–1 mM)) increases glycolysis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MEF(Wt, Bax only, Bak only)
-
Concentration:0.1 nM, 1 nM, 10 nM, 100 nM, 10000 nM
-
Incubation Time:24 h((WT and Bax-only), 48 h (Bak-only)
-
Result:Showed a dose-dependent suppression of caspase activation in all three types of MEFs.
-
Cell Line:Showed a dose-dependent suppression of caspase activation in all three types of MEFs.
-
Concentration:0 nM, 1.6 nM,8 nM, 40 nM, 200 nM, 10 μM
-
Incubation Time:4 h
-
Result:Suppressed STS-induced caspase activation in a dose-dependent manner.
-
Cell Line:Neuro2a
-
Concentration:0 nM, 40 nM, 200 nM, 10 μM
-
Incubation Time:24 h
-
Result:Suppressed Etoposide -induced caspase activation in a dose-dependent manner.
-
Cell Line:ARPE19
-
Concentration:500 nM
-
Incubation Time:24 h
-
Result:Significantly inhibited Obatoclax-induced apoptosis in ARPE19 cells comparing to control.
-
Cell Line:iBax cells
-
Concentration:500 nM
-
Incubation Time:48 h
-
Result:The frequency of the punctuated staining was significantly reduced by M109S.
M109S(i.p., 1 mg/kg, i.v., 5 mg/kg, or o.p., 10 mg/kg) is an orally bioactive cell death inhibitor penetrating blood-brain/retina-barrier[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Abca4-/-Rdh8-/- mice
-
Dosage:10mg/kg
-
Administration:Oral Gavage (PO)
-
Result:Comparing to micewith M109S, the number of AF spots was similar to that detected in the dark-adapted mice
-
Animal Model:Mice and Rat
-
Dosage:Intraperitoneal injection (IP, 1 mg/kg), Intravenous injection (IV, 5 mg/kg), or Oral gavage (OP, 10 mg/kg).
-
Administration:Intraperitoneal injection (IP, 1 mg/kg), Intravenous injection (IV, 5 mg/kg), or Oral gavage (OP, 10 mg/kg).
-
Result:In mice, M109S reached 1.0 mg/mL (2.6 mM) plasma concentration within 30 min from administration, and it remained at 596± 134 ng/mL (1.6± 0.36 mM) 24 h after the oral gavage administration, the same as in rat. At 24 h after the oral gavage administration, the level of M109S in the plasma was 565.3± 188.3 nM in rats.The level of M109S in the rat retina and brain reached 171.0± 52.0 nM and 222.7± 74.7 nM, respectively, 24 h after its oral administration.
Chemical Information
-
No. CAS 2983122-03-6
-
Peso molecular 475.53
-
Fòrmula C28H29NO6
-
SMILES
O=C1C=C[C@]2(O)[C@]1(C)[C@H](OC([C@]3(C(C(C4=CC=CC=C45)=O)6C5=O)C[C@@H]7N6CCC7)=O)[C@H]3CC[C@@H]2C
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 160 Related Classifications
HY-156186 Related Classifications
Powered by Bioz