Antimalarial agent 14
Based on 1 Customer Validation
Antimalarial agent 14 (Compound N3) is a potent inhibitor of mitochondrial electron transport. Antimalarial agent 14 can serve as an anti-malarial agent.
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- Pureza: 99.33%
- No. CAS: 1150-59-0
- Fòrmula: C16H10O3
- Peso molecular:250.25
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Actividad biológica
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Plasmodium |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Peritoneal macrophage | CC50 |
1988 μM
Compound: AN-04
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Cytotoxicity against Swiss Webster mouse peritoneal macrophages by LDH release assay
Cytotoxicity against Swiss Webster mouse peritoneal macrophages by LDH release assay
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[PMID: 29133043] |
| Peritoneal macrophage | IC50 |
0.0112 μM
Compound: AN-04
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Antiinflammatory activity in LPS/IFNgamma-differentiated Swiss Webster mouse peritoneal macrophages assessed as inhibition of ATP-induced IL-1beta release preincubated for 15 mins followed by ATP/LPS challenge measured after 30 mins by sandwich ELISA
Antiinflammatory activity in LPS/IFNgamma-differentiated Swiss Webster mouse peritoneal macrophages assessed as inhibition of ATP-induced IL-1beta release preincubated for 15 mins followed by ATP/LPS challenge measured after 30 mins by sandwich ELISA
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[PMID: 29133043] |
| THP-1 | IC50 |
0.0098 μM
Compound: AN-04
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Antiinflammatory activity in LPS/IFNgamma-differentiated human THP1 cells assessed as inhibition of ATP-induced IL-1beta release after 30 mins by ELISA
Antiinflammatory activity in LPS/IFNgamma-differentiated human THP1 cells assessed as inhibition of ATP-induced IL-1beta release after 30 mins by ELISA
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[PMID: 29133043] |
Antimalarial agent 14 (Compound N3) (0-400 μM, 48 h) inhibits P. falciparum with limited cytotoxicity against human cells[1].
Antimalarial agent 14 inhibits P. falciparum mitochondrial membrane potential with an IC50ΔΨmit of 16 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:P. falciparum and HEK293T
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Concentration:0.128, 0.64, 3.2, 16, 80 and 400 μM
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Incubation Time:48 h
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Result:Showed inhibition with an IC50 of 443 nM against P. falciparum and showed cytotoxicity with a CC50 of 54.6 ± 0.23 μM.
Chemical Information
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No. CAS 1150-59-0
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Appearance Solid
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Peso molecular 250.25
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Fòrmula C16H10O3
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Color Yellow to brown
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SMILES
O=C1C(O)=C(C2=CC=CC=C2)C(C3=C1C=CC=C3)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 125 mg/mL (499.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9960 mL | 19.9800 mL | 39.9600 mL | 99.9001 mL |
| 5 mM | 0.7992 mL | 3.9960 mL | 7.9920 mL | 19.9800 mL | |
| 10 mM | 0.3996 mL | 1.9980 mL | 3.9960 mL | 9.9900 mL | |
| 15 mM | 0.2664 mL | 1.3320 mL | 2.6640 mL | 6.6600 mL | |
| 20 mM | 0.1998 mL | 0.9990 mL | 1.9980 mL | 4.9950 mL | |
| 25 mM | 0.1598 mL | 0.7992 mL | 1.5984 mL | 3.9960 mL | |
| 30 mM | 0.1332 mL | 0.6660 mL | 1.3320 mL | 3.3300 mL | |
| 40 mM | 0.0999 mL | 0.4995 mL | 0.9990 mL | 2.4975 mL | |
| 50 mM | 0.0799 mL | 0.3996 mL | 0.7992 mL | 1.9980 mL | |
| 60 mM | 0.0666 mL | 0.3330 mL | 0.6660 mL | 1.6650 mL | |
| 80 mM | 0.0500 mL | 0.2498 mL | 0.4995 mL | 1.2488 mL | |
| 100 mM | 0.0400 mL | 0.1998 mL | 0.3996 mL | 0.9990 mL |
Antimalarial agent 14 Related Classifications
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