Bathocuproine
Based on 1 Customer Validation
Bathocuproine is a phenanthroline chelator that binds specifically to Cu+. Bathocuproine preferentially binds Cu+ over Cu2+ to form a chromogenic complex, which is used to detect the oxidation state of copper in biomolecules. Bathocuproine undergoes concentration-dependent self-association to form dimers, and it can engage in aromatic stacking interactions with aromatic residues of Aβ (Kd ≈ 1 mM). Bathocuproine is applicable to research related to Alzheimer's disease.
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- Pureza: 97.0%
- No. CAS: 4733-39-5
- Fòrmula: C26H20N2
- Peso molecular:360.46
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Almacenamiento:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| ScN2a | IC50 |
80 nM
Compound: Bathocuproine
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Inhibition of PrP-res formation in mouse ScN2a cells relative to control
Inhibition of PrP-res formation in mouse ScN2a cells relative to control
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[PMID: 16987659] |
Bathocuproine (0.32-3.16 mM) undergoes reversible monomer-dimer self-association in aqueous solution at 25 °C, with an association constant of 0.64 mM-1.
Bathocuproine (0.32-3.16 mM) binds to the Aβ40 peptide only in its dimeric form in aqueous solution at 25 °C, with a dissociation constant of approximately 1 mM under conditions where the dimer accounts for ≥ 40% of the total[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 4733-39-5
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Appearance Solid
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Peso molecular 360.46
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Fòrmula C26H20N2
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Color Light yellow to brown
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SMILES
N=1C(=CC(C=2C=CC=CC2)=C3C=CC4=C(N=C(C=C4C=5C=CC=CC5)C)C13)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Chen D, et al. An improved Bathocuproine assay for accurate valence identification and quantification of copper bound by biomolecules. Anal Biochem. 2016;497:27-35. [Content Brief]
[2]. Yao S, et al. Characterizing bathocuproine self-association and subsequent binding to Alzheimer's disease amyloid beta-peptide by NMR. J Pept Sci. 2004;10(4):210-217. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Bathocuproine Related Classifications
HY-D0005 Related Classifications
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