BBT
Based on 1 Customer Validation
BBT is an enhancer of impaired glucose-stimulated insulin secretion (GSIS). BBT exhibits anti-hyperglycemia activity, and protects β-cells from cytokine- or streptozotocin (STZ (HY-13753))-induced cell death in type 2 diabetes models. BBT acts function via cAMP/PKA and long-lasting (L-type) voltage-dependent Ca2+ channel/CaMK2 pathway.
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- Pureza: 99.71%
- No. CAS: 445000-45-3
- Fòrmula: C18H12BrNO2S
- Peso molecular:386.26
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
L-type voltage-dependent Ca2+ channel/CaMK2[1]
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 445000-45-3
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Appearance Solid
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Peso molecular 386.26
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Fòrmula C18H12BrNO2S
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Color Light yellow to brown
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SMILES
C1(=CC=C(Br)S1)C(=O)NC1=CC=CC=C1C(C1C=CC=CC=1)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 125 mg/mL (323.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5889 mL | 12.9446 mL | 25.8893 mL | 64.7232 mL |
| 5 mM | 0.5178 mL | 2.5889 mL | 5.1779 mL | 12.9446 mL | |
| 10 mM | 0.2589 mL | 1.2945 mL | 2.5889 mL | 6.4723 mL | |
| 15 mM | 0.1726 mL | 0.8630 mL | 1.7260 mL | 4.3149 mL | |
| 20 mM | 0.1294 mL | 0.6472 mL | 1.2945 mL | 3.2362 mL | |
| 25 mM | 0.1036 mL | 0.5178 mL | 1.0356 mL | 2.5889 mL | |
| 30 mM | 0.0863 mL | 0.4315 mL | 0.8630 mL | 2.1574 mL | |
| 40 mM | 0.0647 mL | 0.3236 mL | 0.6472 mL | 1.6181 mL | |
| 50 mM | 0.0518 mL | 0.2589 mL | 0.5178 mL | 1.2945 mL | |
| 60 mM | 0.0431 mL | 0.2157 mL | 0.4315 mL | 1.0787 mL | |
| 80 mM | 0.0324 mL | 0.1618 mL | 0.3236 mL | 0.8090 mL | |
| 100 mM | 0.0259 mL | 0.1294 mL | 0.2589 mL | 0.6472 mL |
BBT Related Classifications
HY-Q40876 Related Classifications
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