Referencia número: HY-105858

H-Ile-Trp-OH

Name: H-Ile-Trp-OH
Brand: MedChemExpress
SKU: HY-105858
Price: 30.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: Ile-Trp)

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H-Ile-Trp-OH (Ile-Trp), a dipeptide, is an angiotensin-converting enzyme (ACE) inhibitor with an IC₅₀ of 0.7 μM. H-Ile-Trp-OH inhibits predominantly the C-domain of ACE.

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Pureza: 98.04%
No. CAS: 13589-06-5
Fòrmula: C₁₇H₂₃N₃O₃
Peso molecular:317.38

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

H-Ile-Trp-OH Chemical Structure

No. CAS: 13589-06-5

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vivo
- Ensayo clínico
Chemical Information
Solvente y solubilidad
- In Vitro
- In Vivo
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

H-Ile-Trp-OH (Ile-Trp), a dipeptide, is an angiotensin-converting enzyme (ACE) inhibitor with an IC₅₀ of 0.7 μM. H-Ile-Trp-OH inhibits predominantly the C-domain of ACE^[1].

IC₅₀ & Target

α7 nAChR^[1].

In Vivo

H-Ile-Trp-OH (0.1-10 mg/kg) increases the time spent and the distance travelled in the open arms of the maze in mice^[4].

Mean pharmacokinetic parameters following oral administration of H-Ile-Trp-OH to male Sprague Dawley rats at doses of 0.5, 5 and 100 mg/kg^[3]

Parameter	Measured Dose (mg/kg)	Apparent t_half (h)	C_max (μM)	T_max (min)	AUC_0-tlast (μM*min)	AUC_0-inf (μM*min)	AUC_0-inf/D (μMminkg/μmol)	Apparent BA (%)	% Dose in urine
0.5 mg/kg	0.55	c.n.c.	0.2	30	53.8	c.n.c.	41.4	66.7	1.6
5 mg/kg	4.8	8.8	1.1	30/300/30	496.8	497.6	43.7	70.3	0.7
100 mg/kg	102.4	6.3	5.7	150	3055.1	3062.9	12.5	13.2	0.2

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ensayo clínico

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

No. CAS 13589-06-5
Appearance Solid
Peso molecular 317.38
Fòrmula C₁₇H₂₃N₃O₃
Color White to off-white
SMILES

O=C([C@@H](N)[C@@H](C)CC)N[C@H](C(O)=O)CC1=CNC2=C1C=CC=C2
Synonyms

Ile-Trp
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvente y solubilidad

In Vitro:

DMSO : 125 mg/mL (393.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.1508 mL

15.7540 mL

31.5080 mL

5 mM

0.6302 mL

3.1508 mL

6.3016 mL

10 mM

0.3151 mL

1.5754 mL

3.1508 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (6.55 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (6.55 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (6.55 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (277 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Huettner C, et al. Tailoring the Adsorption of ACE-Inhibiting Peptides by Nitrogen Functionalization of Porous Carbons. Langmuir. 2019 Jul 30;35(30):9721-9731. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.1508 mL	15.7540 mL	31.5080 mL	78.7699 mL
	5 mM	0.6302 mL	3.1508 mL	6.3016 mL	15.7540 mL
	10 mM	0.3151 mL	1.5754 mL	3.1508 mL	7.8770 mL
	15 mM	0.2101 mL	1.0503 mL	2.1005 mL	5.2513 mL
	20 mM	0.1575 mL	0.7877 mL	1.5754 mL	3.9385 mL
	25 mM	0.1260 mL	0.6302 mL	1.2603 mL	3.1508 mL
	30 mM	0.1050 mL	0.5251 mL	1.0503 mL	2.6257 mL
	40 mM	0.0788 mL	0.3938 mL	0.7877 mL	1.9692 mL
	50 mM	0.0630 mL	0.3151 mL	0.6302 mL	1.5754 mL
	60 mM	0.0525 mL	0.2626 mL	0.5251 mL	1.3128 mL
	80 mM	0.0394 mL	0.1969 mL	0.3938 mL	0.9846 mL
	100 mM	0.0315 mL	0.1575 mL	0.3151 mL	0.7877 mL

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H-Ile-Trp-OH