CBLC100
Based on 1 Customer Validation
CBLC100 is an anticancer compound that targets FACT, while inhibiting NF-κB and activating p53. CBLC100 induces cytotoxicity through p53-dependent apoptotic and non-apoptotic pathways. CBLC100 is applicable to the research of cancers such as fibrosarcoma.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 1197996-83-0
- Fòrmula: C24H26N2O2
- Peso molecular:374.48
-
Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Protocolo
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
Descripciòn
In Vitro
CBLC100 potently activates p53 and inhibits NF-κB in cell-based reporter gene assays, with corresponding EC50 values of 0.03 μM and 0.06 μM[1].
CBLC100 exerts selective cytotoxicity against human fibrosarcoma HT1080 cells, while showing low toxicity toward normal human Wi38 diploid fibroblasts[1].
CBLC100 (0.2 μM; 1 h) traps the FACT complex on the chromatin of human fibrosarcoma HT1080 cells, while depleting soluble FACT subunits in the nucleoplasm[1].
CBLC100 enhances CK2-mediated phosphorylation of the C-terminal region of p53 in human fibrosarcoma HT1080 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
No. CAS 1197996-83-0
-
Appearance Solid
-
Peso molecular 374.48
-
Fòrmula C24H26N2O2
-
Color Off-white to light brown
-
SMILES
O=C1CCC2=C1C=CC3=C2C4=C(C=CC5=C4CCC5=O)N3CCN(CC)CC
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
-
Ficha de datos (276 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CBLC100 Related Classifications
HY-124922 Related Classifications
Powered by Bioz