CH5447240
CH5447240 is an agonist for parathyroid hormone receptor 1 (PTHR1), that inhibits human PTHR1 with an EC50 of 12 μM. CH5447240 exhibits good metabolic stability in human liver microsomes. CH5447240 increases serum calcium levels in rats. CH5447240 can be used in research about hypoparathyroidism.
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- No. CAS: 1253919-92-4
- Fòrmula: C26H39N5O4S
- Peso molecular:517.68
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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PTH1R 12 μM (EC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| LLC-PK1 | EC50 |
12 μM
Compound: 1; CH5447240
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Agonist activity at recombinant human PTHR1 expressed in pig LLC-PK1 cells assessed as increase in cAMP production measured after 20 mins by EIA
Agonist activity at recombinant human PTHR1 expressed in pig LLC-PK1 cells assessed as increase in cAMP production measured after 20 mins by EIA
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[PMID: 32022560] |
Chemical Information
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No. CAS 1253919-92-4
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Peso molecular 517.68
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Fòrmula C26H39N5O4S
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SMILES
O=C(N)N(C1=CC(C)=C(CCS(=O)(N(CC2)CCC2(NC([C@H]3CC[C@H](C)CC3)=N4)C4=O)=O)C(C)=C1)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CH5447240 Related Classifications
HY-120398 Related Classifications
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