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Referencia número: HY-113662

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CLB-016

CLB-016 is a potent Hypoxia-inducible factor (HIF-1) inhibitor with an IC₅₀ of 19.1 μM. CLB-016 significantly suppresses HIF-1-mediated hypoxia response.

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No. CAS: 1005636-29-2
Fòrmula: C₁₇H₂₀N₆O₃
Peso molecular:356.38

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

CLB-016 Chemical Structure

No. CAS: 1005636-29-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- Cellular Effect
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Actividad biológica

Descripciòn

CLB-016 is a potent Hypoxia-inducible factor (HIF-1) inhibitor with an IC₅₀ of 19.1 μM. CLB-016 significantly suppresses HIF-1-mediated hypoxia response^[1].

Ver todos los productos específicos de isoformas HIF/HIF Prolyl-Hydroxylase :

Cellular Effect

Cell Line	Type	Value	Description	References
HT-1080	IC₅₀	15.1 μM Compound: 1, CLB-016	Inhibition of cell proliferation of human HT1080 cells after 72 hrs by WST-8 dye based cell counting assay Inhibition of cell proliferation of human HT1080 cells after 72 hrs by WST-8 dye based cell counting assay	[PMID: 25773014]
HT-1080	IC₅₀	19.1 μM Compound: 1, CLB-016	Inhibition of HIF1 in human HT1080 cells transfected with 5xHRE/pGL3/VEGF/E1b reporter plasmid pre-incubated for 1 hr followed by incubation under hypoxia conditions for 24 hrs by HRE-driven luciferase reporter gene assay Inhibition of HIF1 in human HT1080 cells transfected with 5xHRE/pGL3/VEGF/E1b reporter plasmid pre-incubated for 1 hr followed by incubation under hypoxia conditions for 24 hrs by HRE-driven luciferase reporter gene assay	[PMID: 25773014]

Chemical Information

No. CAS 1005636-29-2
Peso molecular 356.38
Fòrmula C₁₇H₂₀N₆O₃
SMILES

O=C(C1=NN(CC)C=C1NC(C2=CC=C(CN3N=C(C)C=C3C)O2)=O)N
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Yasuda Y, et al. Design, synthesis, and structure-activity relationships of 1-ethylpyrazole-3-carboxamide compounds as novel hypoxia-inducible factor (HIF)-1 inhibitors. Bioorg Med Chem. 2015 Apr 15;23(8):1776-87. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Actividad biológica
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CLB-016

Ver todos los productos específicos de isoformas HIF/HIF Prolyl-Hydroxylase

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

CLB-016 Related Classifications

HY-113662 Related Classifications