CLB-016
CLB-016 is a potent Hypoxia-inducible factor (HIF-1) inhibitor with an IC50 of 19.1 μM. CLB-016 significantly suppresses HIF-1-mediated hypoxia response.
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- No. CAS: 1005636-29-2
- Fòrmula: C17H20N6O3
- Peso molecular:356.38
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-1080 | IC50 |
15.1 μM
Compound: 1, CLB-016
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Inhibition of cell proliferation of human HT1080 cells after 72 hrs by WST-8 dye based cell counting assay
Inhibition of cell proliferation of human HT1080 cells after 72 hrs by WST-8 dye based cell counting assay
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[PMID: 25773014] |
| HT-1080 | IC50 |
19.1 μM
Compound: 1, CLB-016
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Inhibition of HIF1 in human HT1080 cells transfected with 5xHRE/pGL3/VEGF/E1b reporter plasmid pre-incubated for 1 hr followed by incubation under hypoxia conditions for 24 hrs by HRE-driven luciferase reporter gene assay
Inhibition of HIF1 in human HT1080 cells transfected with 5xHRE/pGL3/VEGF/E1b reporter plasmid pre-incubated for 1 hr followed by incubation under hypoxia conditions for 24 hrs by HRE-driven luciferase reporter gene assay
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[PMID: 25773014] |
Chemical Information
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No. CAS 1005636-29-2
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Peso molecular 356.38
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Fòrmula C17H20N6O3
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SMILES
O=C(C1=NN(CC)C=C1NC(C2=CC=C(CN3N=C(C)C=C3C)O2)=O)N
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CLB-016 Related Classifications
HY-113662 Related Classifications
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