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Referencia número: HY-N3619

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Conophylline

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Conophylline is a vinca alkaloid extracted from leaves of a tropical plant Ervatamia microphylla. Conophylline is a differentiation inducer of for pancreatic cells. Conophylline suppresses HSC and induces apoptosis.

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Pureza: 98.04%
No. CAS: 142741-24-0
Fòrmula: C₄₄H₅₀N₄O₁₀
Peso molecular:794.89

Almacenamiento:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Conophylline Chemical Structure

No. CAS: 142741-24-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (1)
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Actividad biológica

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.17 μM Compound: 65	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth Antiproliferative activity against human A549 cells assessed as inhibition of cell growth	[PMID: 36170798]
A549	IC₅₀	0.21 μM Compound: Conophylline	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 23944995]
A549	IC₅₀	3.2 μM Compound: 5	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 30869890]
HCT-116	IC₅₀	0.8 μM Compound: 5	Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 30869890]
HL-60	IC₅₀	0.17 μM Compound: 65	Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth Antiproliferative activity against human HL-60 cells assessed as inhibition of cell growth	[PMID: 36170798]
HL-60	IC₅₀	0.17 μM Compound: Conophylline	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 23944995]
HT-29	IC₅₀	3 μM Compound: 5	Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay	[PMID: 30869890]
KB/VJ300	IC₅₀	>10 μM Compound: 5	Cytotoxicity against human KB/VJ300 cells after 72 hrs by MTT assay Cytotoxicity against human KB/VJ300 cells after 72 hrs by MTT assay	[PMID: 30869890]
KB/VJ300	IC₅₀	4.9 μM Compound: 5	Cytotoxicity against human KB/VJ300 cells after 72 hrs in presence of vincristine by MTT assay Cytotoxicity against human KB/VJ300 cells after 72 hrs in presence of vincristine by MTT assay	[PMID: 30869890]
LNCaP	IC₅₀	>10 μM Compound: 5	Cytotoxicity against human LNCAP cells after 72 hrs by MTT assay Cytotoxicity against human LNCAP cells after 72 hrs by MTT assay	[PMID: 30869890]
MCF7	IC₅₀	0.17 μM Compound: 65	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth	[PMID: 36170798]
MCF7	IC₅₀	1.02 μM Compound: Conophylline	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 23944995]
MCF7	IC₅₀	2.1 μM Compound: 5	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 30869890]
MDA-MB-231	IC₅₀	1.6 μM Compound: 5	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay	[PMID: 30869890]
PC-3	IC₅₀	0.3 μM Compound: 5	Cytotoxicity against human PC3 cells after 72 hrs by MTT assay Cytotoxicity against human PC3 cells after 72 hrs by MTT assay	[PMID: 30869890]
SMMC-7721	IC₅₀	0.17 μM Compound: 65	Antiproliferative activity against human SMMC-7721 cells assessed as inhibition of cell growth Antiproliferative activity against human SMMC-7721 cells assessed as inhibition of cell growth	[PMID: 36170798]
SW480	IC₅₀	0.17 μM Compound: 65	Antiproliferative activity against human SW480 cells assessed as inhibition of cell growth Antiproliferative activity against human SW480 cells assessed as inhibition of cell growth	[PMID: 36170798]
SW480	IC₅₀	1.49 μM Compound: Conophylline	Cytotoxicity against human SW480 cells after 48 hrs by MTT assay Cytotoxicity against human SW480 cells after 48 hrs by MTT assay	[PMID: 23944995]

In Vitro

Conophylline (100 ng/ml; 48 hours) reproduces differentiationinducing activity but not apoptosis-inducing activity of activin^[1].
? Conophylline (100 ng/ml; 72 hours) exhibits the differentiation-inducing activity in AR42J cells and converts these cells to endocrine cells^[1].
? Conophylline increases the expression of neurogenin-3 by activating p38 mitogen-activated protein kinase to induce differentiation of AR42J cells^[1].
? Conophylline reduces the expression of α-SMA and collagen-1 in rat HSC and Lx-2 cells^[2].
? Conophylline inhibits DNA synthesis induced by serum^[2].
? Conophylline also promots activation of caspase-3 and induces apoptosis in Lx-2 Cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[2]

Cell Line:

Lx-2 Cells
Concentration:

12 hours
Incubation Time:

0.1 μg/ml
Result:

Induced apoptosis

Western Blot Analysis^[2]

Cell Line:

Lx-2 cells
Concentration:

0.1 μg/ml
Incubation Time:

15 minutes, 30 minutes, 60 minutes, 120 minutes
Result:

Increased phospho-JNK.

In Vivo

Conophylline (0.9 mg/kg; p.o.; daily; for 12 weeks) attenuates formation of the liver fibrosis induced by TAA in vivo^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley rats (70-80 g)^[2]
Dosage:

0.9 mg/kg
Administration:

Oral administration; daily; for 12 weeks
Result:

Attenuated formation of the liver fibrosis induced by TAA.

Chemical Information

No. CAS 142741-24-0
Appearance Solid
Peso molecular 794.89
Fòrmula C₄₄H₅₀N₄O₁₀
Color Off-white to light yellow
SMILES

CC[C@]1(C2)[C@@]3([H])[C@](C4=CC(O)=C5OC)(CCN3[C@@](C(C=C([C@]6(CCN7C[C@]8([H])[C@@]9([H])O8)[C@]7([H])[C@@]9(C%10)CC)C(NC6=C%10C(OC)=O)=C%11)=C%11O%12)([H])[C@@]%12([H])[C@H]1O)C(NC4=C5OC)=C2C(OC)=O
Structure Classification
- Alkaloids
- Indole Alkaloids
- Phenols
- Monophenols
Initial Source
- Plants
- other families
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Mol Pharmacol

Thermal Proteome Profiling Reveals Glutathione Peroxidase 4 as the Target of the Autophagy Inducer Conophylline. [Abstract]

2021 Sep;100(3):181-192. PMID: 34127539

Pureza y Documentación

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Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (282 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Kojima I, et al. Conophylline: a novel differentiation inducer for pancreatic beta cells. Int J Biochem Cell Biol. 2006;38(5-6):923-30. [Content Brief]

[2]. Kubo N, et al. Conophylline suppresses hepatic stellate cells and attenuates thioacetamide-induced liver fibrosis in rats. Liver Int. 2014 Aug;34(7):1057-67. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Conophylline

1 Cited Publications

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Conophylline

Publications Citing Use of MedChemExpress (MCE) Conophylline

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