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Referencia número: HY-Z16793

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Cornigerine

Name: Cornigerine
Brand: MedChemExpress
SKU: HY-Z16793
Availability: PreOrder

(Synonyms: Colchicine impurity H)

Cornigerine (Colchicine impurity H) is an antimitotic agent and tubulin antagonist. Cornigerine inhibits tubulin polymerization, blocks colchicine binding to tubulin, and stimulates tubulin-dependent GTP hydrolysis. Cornigerine induces metaphase arrest in leukemia cells and exhibits toxic activity against leukemia cells. Cornigerine can be used in research on mouse leukemia.

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No. CAS: 6877-25-4
Fòrmula: C₂₁H₂₁NO₆
Peso molecular:383.40

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Cornigerine Chemical Structure

No. CAS: 6877-25-4

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Actividad biológica
- Descripciòn
- Cellular Effect
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
L1210	IC50	0.02-0.04 μM	Inhibition of murine leukemia L1210 cell growth assessed after 24 hours incubation. Inhibition of murine leukemia L1210 cell growth assessed after 24 hours incubation.	0006295288903723

In Vitro

Anti-cancerCell Cycle RegulationOthers

Anti-cancer

Cell Cycle Regulation

Cornigerine (0.01-0.3 μM; 6-24 h) potently inhibits the growth of L1210 mouse leukemia cells with an IC₅₀ of 0.02-0.04 μM and induces mitotic arrest in these cells^[1].

Others

Cornigerine (0.1 mM; 0-60 min; 37°C) inhibits the early phase of tubulin-dependent GTP hydrolysis by purified bovine brain tubulin (assembled with heat-treated microtubule-associated proteins)^[1].
Cornigerine is a microtubule assembly inhibitor that is more potent than colchicine in a reconstituted system containing purified bovine brain tubulin and heat-treated microtubule-associated proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

L1210 murine leukemia cells
Concentration:

0.01-0.3 μM (cell growth assay); 0.01-0.3 μM (mitotic arrest assay)
Incubation Time:

24 h (cell growth assay); 6 h (mitotic arrest assay)
Result:

Inhibited L1210 cell growth with an IC₅₀ ranging from 0.02 to 0.04 μM.
Caused accumulation of cells arrested in mitosis at cytotoxic concentrations.

Chemical Information

No. CAS 6877-25-4
Peso molecular 383.40
Fòrmula C₂₁H₂₁NO₆
SMILES

O(C)C1=C2C=3C([C@@H](NC(C)=O)CCC2=CC4=C1OCO4)=CC(=O)C(OC)=CC3
Synonyms

Colchicine impurity H
Structure Classification
- Others
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Hamel E, et al. Cornigerine, a potent antimitotic Colchicum alkaloid of unusual structure: interactions with tubulin[J]. Biochemical pharmacology, 1988, 37(12): 2445-2449.

[2]. Roesner M, et al. Synthesis of two aromatic methylenedioxy-substituted colchicine congeners: elucidation of the structure of cornigerine as 2, 3-(methylenedioxy)-2, 3-didemethoxycolchicine[J]. The Journal of Organic Chemistry, 1981, 46(18): 3686-3688.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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