CVN293
Based on 1 Customer Validation
CVN293 is a selective and brain permeable potassium ion (K+) channel KCNK13 inhibtor with IC50s of 41 nM and 28 nM for hKCNK13 and mKCNK13, respectively. CVN293 potently inhibits the NLRP3-inflammasome mediated production of the proinflammatory cytokine IL-1β in microglia.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.91%
- No. CAS: 2815296-08-1
- Fòrmula: C14H10FN7O
- Peso molecular:311.27
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
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hKCNK13 41 nM (IC50) |
mKCNK13 28 nM (IC50) |
hKCNK6 >30000 nM (IC50) |
hKCNK2 >30000 nM (IC50) |
CVN293 (0.05, 0.5, 5 μM) demonstrates a concentration-dependent inhibition of the NLRP3-inflammasome mediated production of IL-1β from LPS-primed murine microglia[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| IV (0.5 mg/kg; rat) | PO (3 mg/kg; rat) | IV (1 mg/kg; dog) | PO (10 mg/kg; dog) | IV (1 mg/kg; cynomolgus monkey) | PO (3 mg/kg; cynomolgus monkey) | |
| Tmax (h) | 1.0 | 1.25 | 1.0 | |||
| Cmax (ng/mL) | 468 | 241 | 165 | |||
| AUC0-∞ (ng•h/mL) | 222 | 1236 | 438 | 630 | 782 | 546 |
| t1/2 (h) | 1.0 | 2.0 | 0.5 | 2.6 | 1.1 | 1.9 |
| CLp (mL/min/kg) | 35 | 38 | 22 | |||
| Vss (L/kg) | 1.85 | 1.42 | 1.45 | |||
| F (%) | 87 | 41 | 24 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2815296-08-1
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Appearance Solid
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Peso molecular 311.27
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Fòrmula C14H10FN7O
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Color White to light yellow
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SMILES
NC1=NON=C1C2=NC3=CC=CC(F)=C3N2CC4=NN=CC=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 5 mg/mL (16.06 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (282 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2126 mL | 16.0632 mL | 32.1265 mL | 80.3161 mL |
| 5 mM | 0.6425 mL | 3.2126 mL | 6.4253 mL | 16.0632 mL | |
| 10 mM | 0.3213 mL | 1.6063 mL | 3.2126 mL | 8.0316 mL | |
| 15 mM | 0.2142 mL | 1.0709 mL | 2.1418 mL | 5.3544 mL |
CVN293 Related Classifications
HY-158155 Related Classifications
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