D-(+)-Trehalose
Based on 11 publication(s) in Google Scholar
D-(+)-Trehalose (α,α-Trehalose) is an orally active disaccharide, showing anti-desiccant and cryopreservative activities. D-(+)-Trehalose acts as an osmolyte, and stress protectant and helps in the storage and transport of carbon. D-(+)-Trehalose can be used as a food ingredient and pharmaceutical excipient.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.95%
- No. CAS: 99-20-7
- Fòrmula: C12H22O11
- Peso molecular:342.30
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Almacenamiento:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) D-(+)-Trehalose
More- ACS Nano. 2025 May 27;19(20):19233-19254. [Abstract]
- Extracell Vesicles Circ Nucl Acids. 2026 Jul 31;7(3):1228-48.
- Food Funct. 2026 May 18. [Abstract]
- Int J Pharm. 2024 Oct 25:664:124608. [Abstract]
- Microchem J. 2024 Jun, 201, 110666.
- Ren Fail. 2024 Dec;46(1):2338933. [Abstract]
- Plant Pathol. 2025 Dec 30.
- J Ocul Pharmacol Ther. 2022 Jun;38(5):331-338. [Abstract]
- Res Sq. 2025 Oct 9.
- Res Sq. 2025 Jul 13.
- Res Sq. 2024 Sep 30.
Customer Validation & Images
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Cell Autophagy Assay
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Cell Proliferation/Viability Assay
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WB
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Cell Autophagy Assay
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RT-PCR
Ver todos los productos específicos de isoformas Endogenous Metabolite
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Actividad biológica
Descripciòn
IC50 & Target
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Microbial Metabolite |
Human Endogenous Metabolite |
In Vitro
D-(+)-Trehalose (5000 μg/mL, 21 h) has no toxic effects on Chinese hamster ovary (CHO) cells[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice and rats[4]
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Dosage:1-16 g/kg
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Administration:p.o. or i.v., a single dose for 14 days
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Result:Resulted in mild, self-limiting and restricted to piloerection and a softening of feces and modest trehalose dose-dependent increases in blood glucose levels.
Chemical Information
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No. CAS 99-20-7
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Appearance Solid
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Peso molecular 342.30
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Fòrmula C12H22O11
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Color White to off-white
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SMILES
O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@H]1O[C@@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O
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Synonyms
D-Trehalose; α,α-Trehalose
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Structure Classification
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Initial Source
Widespread
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (11)
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Journal Impact Factor
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Most Recent
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ACS Nano
Trehalose Acts as a Mediator: Imbalance in Brain Proteostasis Induced by Polystyrene Nanoplastics via Gut Microbiota Dysbiosis during Early Life. [Abstract]2025 May 27;19(20):19233-19254. PMID: 40359452 -
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Food Funct
Ameliorative effect of docosahexaenoic acid-acylated astaxanthin ester on diabetic nephropathy: association with the trehalose/HSP90AA1 and colon-kidney axis. [Abstract]2026 May 18. PMID: 42149022 -
Int J Pharm
Development of a proliposomal pretomanid dry powder inhaler as a novel alternative approach for combating pulmonary tuberculosis. [Abstract]2024 Oct 25:664:124608. PMID: 39163929 -
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Ren Fail
TXNIP deficiency attenuates renal fibrosis by modulating mTORC1/TFEB-mediated autophagy in diabetic kidney disease. [Abstract]2024 Dec;46(1):2338933. PMID: 38616177
D-(+)-Trehalose purchased from MedChemExpress. Usage Cited in: Ren Fail. 2024 Dec;46(1):2338933. [Abstract]
D-(+)-Trehalose (Tre) (50 mM; 2 h). The expression of cytoplasmic TFEB and nuclear TFEB was analyzed by western blotting.
D-(+)-Trehalose purchased from MedChemExpress. Usage Cited in: Ren Fail. 2024 Dec;46(1):2338933. [Abstract]
D-(+)-Trehalose (Tre) (50 mM; 2 h). Autophagic vacuoles in HK-2 cells were observed by the transmission electron microscope, and yellow arrows represented autophagic vacuoles (×4,000, or ×30,000).
D-(+)-Trehalose purchased from MedChemExpress. Usage Cited in: Ren Fail. 2024 Dec;46(1):2338933. [Abstract]
D-(+)-Trehalose (Tre) (50 mM; 2 h). The mRNA levels of fibronectin, collagen I, α-SMA and E-cadherin were assessed by RT-qPCR.
D-(+)-Trehalose purchased from MedChemExpress. Usage Cited in: Ren Fail. 2024 Dec;46(1):2338933. [Abstract]
D-(+)-Trehalose (Tre) (50 mM; 2 h). E-cadherin and α-SMA was detected by immunoinfluorence staining (Bar = 25 μm).
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J Ocul Pharmacol Ther
Autophagy Protects Ocular Surface Against Overactivated Inflammation by Degrading Retinoic Acid-Induced Gene-I in Human Conjunctival Epithelial Cells. [Abstract]2022 Jun;38(5):331-338. PMID: 35613408 -
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D-(+)-Trehalose purchased from MedChemExpress. Usage Cited in: Res Sq. 2025 Jul 13.
D-(+)-Trehalose (trehalose) (50 mM; 24 h). Secondary screen cell-based assay for p62 expression. Dot plot representation of the effects of the 17 compounds on p62 expression after 24 hours of treatment and cell viability. Quantification of total p62 puncta area following treatment relative to the control DMSO 0.1%, using HCS Studio software. Each bar represents the mean ± SD (n=3).
D-(+)-Trehalose purchased from MedChemExpress. Usage Cited in: Res Sq. 2025 Jul 13.
D-(+)-Trehalose (trehalose) (50 mM; 24 h). Cell-based screen for drug efficacy on membrane repair phenotype. Measurement of cell mortality after hypo-osmotic shock on DYSFS1173X immortalized myoblasts pretreated for 24 hours with the 17 compounds. Each point represents the mean ± SD (n=4) of a representative experiment from three independent experiments.
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Solvente y solubilidad
In Vitro:
H2O : 200 mg/mL (584.28 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (292.14 mM); Clear solution; Need ultrasonic
Pureza y Documentación
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Ficha de datos (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.9214 mL | 14.6071 mL | 29.2141 mL | 73.0354 mL |
| 5 mM | 0.5843 mL | 2.9214 mL | 5.8428 mL | 14.6071 mL | |
| 10 mM | 0.2921 mL | 1.4607 mL | 2.9214 mL | 7.3035 mL | |
| 15 mM | 0.1948 mL | 0.9738 mL | 1.9476 mL | 4.8690 mL | |
| 20 mM | 0.1461 mL | 0.7304 mL | 1.4607 mL | 3.6518 mL | |
| 25 mM | 0.1169 mL | 0.5843 mL | 1.1686 mL | 2.9214 mL | |
| 30 mM | 0.0974 mL | 0.4869 mL | 0.9738 mL | 2.4345 mL | |
| 40 mM | 0.0730 mL | 0.3652 mL | 0.7304 mL | 1.8259 mL | |
| 50 mM | 0.0584 mL | 0.2921 mL | 0.5843 mL | 1.4607 mL | |
| 60 mM | 0.0487 mL | 0.2435 mL | 0.4869 mL | 1.2173 mL | |
| 80 mM | 0.0365 mL | 0.1826 mL | 0.3652 mL | 0.9129 mL | |
| 100 mM | 0.0292 mL | 0.1461 mL | 0.2921 mL | 0.7304 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
D-(+)-Trehalose Related Classifications
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