DC07090
DC07090 is a potent, reversible and competitive non-peptidyl human enterovirus 71 3C protease inhibitor with an IC50 and a Ki value for 21.72 μM and 23.29 μM. DC07090 could also inhibit coxsackievirus A16 (CVA16) replication with an EC50 value of 27.76 μM.
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- No. CAS: 879070-72-1
- Fòrmula: C18H14N4O
- Peso molecular:302.33
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
IC50: 21.72 μM (EV71 3C protease)[1].
Ki: 23.29 μM (EV71 3C protease)[1].
EC50: 27.76 μM (coxsackievirus A16)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RD | CC50 |
>200 μM
Compound: DC07090
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Cytotoxicity against human RD cells after 48 hrs by CellTiter-glo luminescent cell viability assay
Cytotoxicity against human RD cells after 48 hrs by CellTiter-glo luminescent cell viability assay
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[PMID: 27776325] |
In Vitro
DC07090 forms stable hydrogen-bonding interactions with the main chains of S128, G145, G164 and hydrophobic interactions with F25, L125, L127 and F170. DC07090 (0.01~10 μM) shows micromolar potency against EV71 3Cpro. DC07090 exhibits a highly inhibitory potency on EV71 replication with an EC50 value of 22.09 μM. DC07090 inhibits CVA16 with an EC50 value of 27.76 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 879070-72-1
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Peso molecular 302.33
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Fòrmula C18H14N4O
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SMILES
C1(C(C=C2)=CC=C2NCC3=NC=CC=C3)=NC(N=CC=C4)=C4O1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DC07090 Related Classifications
HY-123517A Related Classifications
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