ddATP
Based on 1 publication(s) in Google Scholar
ddATP (2',3'-Dideoxyadenosine 5'-triphosphate), an active metabolite of 2',3'-dideoxyinosine, is a chain-elongating inhibitor of DNA polymerase. ddATP can be used for Sanger method for DNA sequencing and research of virus infection.
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- No. CAS: 24027-80-3
- Fòrmula: C10H16N5O11P3
- Peso molecular:475.18
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Almacenamiento:
Solution, -20°C, 2 years
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Actividad biológica
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) ddATP
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Actividad biológica
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DNA Polymerase |
ddATP (0.05-50 μM, 30 min) inhibits adenovirus DNA synthesis in isolated nuclei from adenovirus-infected KB cells[1].
ddATP (100 μM, 5 h) reduces the number of γH2A.X foci in the DSB (DNA double-strand breaks) oocytes[3].
ddATP inhibits HIV replication by inhibiting HIV reverse transcriptase[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:DSB oocytes
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Concentration:100 μM
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Incubation Time:5 h
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Result:Suppressed the mtDNA replication without fully suppressed the nuclear DNA replication.
Chemical Information
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No. CAS 24027-80-3
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Appearance Liquid
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Peso molecular 475.18
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Fòrmula C10H16N5O11P3
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Color Colorless to light yellow
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SMILES
NC1=NC=NC2=C1N=CN2[C@H]3CC[C@H](O3)COP(O)(OP(OP(O)(O)=O)(O)=O)=O
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Synonyms
2',3'-Dideoxyadenosine 5'-triphosphate
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Solution, -20°C, 2 years
Publications (1)
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Journal Impact Factor
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Most Recent
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RNA
Improved precision, sensitivity, and adaptability of Ordered Two-Template Relay cDNA library preparation for RNA sequencing. [Abstract]2025 Jan 22;31(2):224-244. PMID: 39626888
Pureza y Documentación
Referencias
[1]. van der Vliet PC, et al. Role of DNA polymerase gamma in adenovirus DNA replication. Mechanism of inhibition by 2',3'-dideoxynucleoside 5'-triphosphates. Biochemistry. 1981 Apr 28;20(9):2628-32. [Content Brief]
[2]. Xu Lan, et al. Simultaneous determination of 2 ,3 -dideoxyinosine and the active metabolite, 2 ,3 -dideoxyadenosine-5 -triphosphate in human peripheral-blood mononuclear cell by HPLC–MS/MS and the application to cell pharmacokinetics. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:337-42. [Content Brief]
[3]. Jun-Yu Ma, et al. Double-strand breaks induce short-scale DNA replication and damage amplification in the fully grown mouse oocytes. Genetics. 2021 Jun 24;218(2):iyab054. [Content Brief]
[4]. C M Perry, et al. Didanosine. An update on its antiviral activity, pharmacokinetic properties and therapeutic efficacy in the management of HIV disease. Drugs. 1996 Dec;52(6):928-62. [Content Brief]
[5]. Hao Z, et al. Factors determining the activity of 2',3'-dideoxynucleosides in suppressing human immunodeficiency virus in vitro. Mol Pharmacol. 1988 Oct;34(4):431-5. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ddATP Related Classifications
HY-128036 Related Classifications
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