Denecimig
Based on 1 Customer Validation
Denecimig (Mim8) is a factor VIII-mimetic bispecific antibody with micromolar human binding affinity for Factor X and Factor IXa. Denecimig binds Factor X and Factor IXa, localizes both to the phospholipid surface, enhances the Factor IXa-mediated activation of Factor X to Factor Xa, and stimulates the proteolytic activity of Factor IXa via its monovalent anti-Factor IXa arm. Denecimig is applicable to research related to hemophilia A.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 95.90%
- No. CAS: 2488745-86-2
- Peso molecular:145.46 kDa
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Human IgG4 kappa
Human
F9 & F10
Denecimig efficiently enhances FX activation by localizing FIXa and FX to phospholipid surfaces, with its anti-FIXa arm alone increasing FIXa proteolytic activity 15,000-fold, and binds FIXa and FX with micromolar dissociation constants[1].
Denecimig (0.1-1000 nM) normalizes thrombin generation in congenital HA plasma with 15-fold greater potency than emicizumab[1].
Mim8 exhibits procoagulant activity in hemophilia A-like blood that is ~13-fold more potent than a sequence identical analog of emicizumab, as measured by peak thrombin generation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Denecimig (Mim8) (up to 3 mg/kg/wk; weekly; 26 weeks) reduces bleeding in cynomolgus monkey hemophilia A models and demonstrates potent pharmacodynamic effects and a favorable safety profile[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG4 kappa
ELISA, FACS, Functional assay
Chemical Information
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No. CAS 2488745-86-2
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Appearance Liquid
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Peso molecular 145.46 kDa
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Color Colorless to light yellow
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SMILES
[Denecimig]
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Synonyms
Mim8
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Envío
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
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Ficha de datos (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Denecimig Related Classifications
HY-P990060 Related Classifications
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