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Referencia número: HY-161566

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DHT/BSA

Name: DHT/BSA
Brand: MedChemExpress
SKU: HY-161566
Price: 410.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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DHT/BSA is an antigen-adjuvant conjugate of DHT (dihydrotestosterone) conjugated to bovine serum albumin (BSA) and a cell-impermeable membrane androgen receptor (mAR) agonist. DHT/BSA exacerbates neuronal apoptosis or induces cellular senescence under oxidative stress, and it rapidly inhibits estradiol synthesis and triggers reward and reinforcement behaviors in the central nervous system. DHT/BSA acts by specifically binding to mAR, triggering NOX/ROS generation, activating the NF-κB inflammatory pathway, or inhibiting signaling pathways such as Akt, without involving the classical nuclear translocation pathway. DHT/BSA can be used in research on Parkinson's disease and androgenetic alopecia.

Para uso exclusivo en investigación. No vendemos a pacientes.

Almacenamiento:

Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

DHT/BSA Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target

^[4]

Caspase-3

Caspase-7

In Vitro

ApoptosisCardiovascular RegulationOxidative StressOthers

Apoptosis

DHT-BSA (10 μM; 8-12 h) inhibits Akt phosphorylation and total expression, activates caspase 3/7, and increases TUNEL-positive apoptotic cells in primary cortical astrocytes^[4].

Cardiovascular Regulation

DHT-BSA (100 nM) induces ANG II (HY-13948) release in a biosensor cell system on rat brain slices (substantia nigra and hippocampal CA1 region), resulting in increased fluorescence intensity^[6].

Oxidative Stress

DHT/BSA (500 nM; 4 h) exacerbates H₂O₂-induced loss of N27 dopaminergic neuronal cells, and this effect is blocked by the NOX inhibitor Apocynin (HY-N0088)^[2].
DHT-BSA (500 nM; 24 h) exacerbates cell death under oxidative stress conditions in N27 and PC12 neuronal cells and C6 glial cells^[8].

Others

DHT/BSA (10 μM; 12 h) sensitizes primary cortical astrocytes to IAA (HY-W661484)-induced LDH release, whereas DHT/BSA alone does not increase LDH release^[4].
DHT-BSA (75 μM; 3 h) significantly inhibits hCG (HY-107953)-stimulated estradiol (E2) production in ovarian tissue fragments of Micropogonias undulatus^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

immortalized 1RB3AN27 (N27) rat dopaminergic neuronal cells
Concentration:

500 nM
Incubation Time:

4 h
Result:

Further increased H₂O₂-induced cell loss.
Apocynin blocked the detrimental effect in the presence of oxidative stress.

Related Protocols :

Chemical Information

Appearance Liquid
Color Colorless to light yellow
SMILES

[DHT/BSA]
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (280 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Holmes S, et al. Effects of Oxidative Stress and Testosterone on Pro-Inflammatory Signaling in a Female Rat Dopaminergic Neuronal Cell Line. Endocrinology. 2016 Jul;157(7):2824-35.

[2]. Tenkorang MAA, et al. NADPH Oxidase Mediates Membrane Androgen Receptor-Induced Neurodegeneration. Endocrinology. 2019 Apr 01;160(4):947-963. [Content Brief]

[3]. Sato SM, et al. Membrane androgen receptors may mediate androgen reinforcement. Psychoneuroendocrinology. 2010 Aug;35(7):1063-73.

[4]. Gatson JW, et al. Activation of a membrane-associated androgen receptor promotes cell death in primary cortical astrocytes. Endocrinology. 2007 May;148(5):2458-64.

[5]. Braun AM, et al. Androgens inhibit estradiol-17β synthesis in Atlantic croaker (Micropogonias undulatus) ovaries by a nongenomic mechanism initiated at the cell surface. Biology of Reproduction. 2003 Nov 1;69(5):1642-50.

[6]. Sumien N, et al. Neurodegenerative Disease: Roles for Sex, Hormones, and Oxidative Stress. Endocrinology. 2021 Nov 01;162(11):bqab185.

[7]. Jung YH, et al. Cyanidin 3-O-arabinoside suppresses DHT-induced dermal papilla cell senescence by modulating p38-dependent ER-mitochondria contacts. Journal of biomedical science. 2022 Mar 07;29(1):17. [Content Brief]

[8]. Duong P, et al. Neuroprotective and neurotoxic outcomes of androgens and estrogens in an oxidative stress environment. Biology of sex differences. 2020 Mar 29;11(1):12. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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