DM-4111
DM-4111, one of the major monohydroxyl metabolites of Tolvaptan (HY-17000), is a potent vasopressin V2 receptor inhibitor. DM-4111 inhibits water reabsorption in the renal tubules, thereby promoting the excretion of electrolyte-free water. DM-4111 is promising for research of cardiovascular diseases.
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- No. CAS: 926035-36-1
- Fòrmula: C26H25ClN2O4
- Peso molecular:464.94
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
Ver todos los productos específicos de isoformas Vasopressin Receptor
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Actividad biológica
Descripciòn
IC50 & Target
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V2 Receptor |
Chemical Information
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No. CAS 926035-36-1
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Peso molecular 464.94
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Fòrmula C26H25ClN2O4
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SMILES
O=C(NC1=CC=C(C(N2CC[C@H](O)[C@H](O)C3=CC(Cl)=CC=C32)=O)C(C)=C1)C4=CC=CC=C4C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Hoshikawa K, et al. Validated liquid chromatography coupled to tandem mass spectrometry method for simultaneous quantitation of tolvaptan and its five major metabolites in human plasma. Ann Clin Biochem. 2019 May;56(3):387-396. [Content Brief]
[2]. Hoshikawa K, et al. Impact of CYP3A5 genotype on tolvaptan pharmacokinetics and their relationships with endogenous markers of CYP3A activity and serum sodium level in heart failure patients. Basic Clin Pharmacol Toxicol. 2020 Apr;126(4):353-363. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DM-4111 Related Classifications
HY-165423 Related Classifications
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