DMT003096
DMT003096 is an Hsp70 inhibitor that inhibits J domain (TAg)-stimulated Hsp70 ATPase activity without affecting endogenous Hsp70 ATP hydrolysis.DMT003096 inhibits breast cancer cell proliferation.DMT003096 can be used for the research of breast cancer.
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- No. CAS: 912361-26-3
- Fòrmula: C54H66N4O10
- Peso molecular:931.12
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
HSP70 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SK-BR-3 | GI50 |
17 μM
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Antiproliferative activity against human SK-BR-3 breast cancer cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay.
Antiproliferative activity against human SK-BR-3 breast cancer cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay.
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18164205 |
In Vitro
DMT003096 (72 h) inhibits the proliferation of SK-BR-3 breast cancer cells with a GI50 of 17 μM[1].
DMT003096 (300 μM) had no significant effect on the endogenous ATP hydrolysis activity of Hsp70 in a cell-free system containing yeast Hsp70 (Ssa1p), and selectively inhibited TAg-stimulated Hsp70 ATP hydrolysis by 4.0-fold[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- BrdU Incorporation Assay
- Somatic Cell Culture
- CFSE Dye Dilution Proliferation Assay
- Dye-dilution cell tracking and proliferation staining
- CCK-8/WST-8 Cell Proliferation Assay
- Protocol for Cell Cycle
- Cell Counting-Based Growth Curve Assay
- Colony Formation (Clonogenic) Assay
- Breast Cancer Modeling
- Cell Viability Determination by MTT Colorimetric Assay
- EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
- Ki-67 Immunostaining Proliferation Assay
- PCNA Immunodetection Proliferation Assay
- Protocol for Cell Counting and Cell Density Analysis
- MTT Cell Proliferation Assay
Chemical Information
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No. CAS 912361-26-3
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Peso molecular 931.12
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Fòrmula C54H66N4O10
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SMILES
O=C(OCC1=CC=CC=C1)C2=C(N(C(NC2C3=CC=CC=C3C4=CC=CC=C4)=O)CCCCCC(N(CCCCCC)C(C(NCCCC)=O)C5=CC=C(C(C(OC)=O)=C5)OCC(OC)=O)=O)C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DMT003096 Related Classifications
HY-12619 Related Classifications
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Keywords
- DMT003096
- 912361-26-3
- DMT 003096
- DMT-003096
- HSP
- SK-BR-3 breast cancer cell
- TAg-stimulated Hsp70 ATP hydrolysis
- endogenous Ssa1p ATPase activity
- breast cancer
- Hsp70 inhibitor
- breast cancer cell proliferation
- breast cancer proliferation
- endogenous Hsp70 ATP hydrolysis
- J domain (TAg)-stimulated Hsp70 ATPase activity
- Inhibitor
- inhibitor
- inhibit