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Referencia número: HY-112005G

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DOPE (GMP)

(Synonyms: Dioleoylphosphatidylethanolamine (GMP); 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (GMP))

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DOPE GMP is DOPE (HY-112005) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOPE (Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine) is an orally active inhibitor of ferroptosis with anti-inflammatory and intestinal barrier maintenance activities. DOPE regulates the expression of ACSL4, SLC7A11 and GPX4 to restore the redox system balance, thereby reducing the levels of lipid peroxides, iron ions and intestinal inflammatory factors (IL-1β and IL-6). DOPE promotes the migration and proliferation of intestinal epithelial cells and increases the level of tight junction proteins; it also destabilizes endosomal membranes, mediates the conjugation of RVG peptides with mesenchymal stem cell-derived exosomes to enhance brain targeting. DOPE can be applied to research related to neonatal necrotizing enterocolitis and Alzheimer's disease.

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No. CAS: 4004-05-1
Fòrmula: C₄₁H₇₈NO₈P
Peso molecular:744.03

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

DOPE (GMP) Chemical Structure

No. CAS: 4004-05-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
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- IC₅₀ & Target
- In Vitro
- In Vivo
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Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target

GPX4

ACSL4

Ver todos los productos específicos de isoformas Glutathione Peroxidase :

GPX1
GPX4

Ver todos los productos específicos de isoformas ACSL Family :

ACSL4
ACSL5

In Vitro

FITC-labeled DOPE GMP (2 h) is internalized by IEC-6 rat intestinal epithelial cells within 2 hours, and fluorescence is detectable in both the cytoplasm and nucleus^[1].
DOPE GMP (5 μg/mL; 1 h) restores the migratory capacity of IEC-6 rat intestinal epithelial cells inhibited by LPS^[1].
DOPE GMP (5 μg/mL; 1 h) restores the migration and proliferation capacities, as well as the expression of tight junction proteins (ZO-1, occludin), in RSL3-induced ferroptotic rat intestinal epithelial cells IEC-6^[1].
DOPE GMP enhances the uptake efficiency of mesenchymal stem cells for AMSC-MP, improves the cell adhesion ability to scaffolds, upregulates the expression of osteogenesis-related gene RUNX2, and enhances in vitro osteogenic differentiation capacity. Moreover, this formulation exhibits excellent biocompatibility and does not exert adverse effects on cell viability^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay ^[1]

Cell Line:

LPS-stimulated rat intestinal epithelial IEC-6 cells
Concentration:

5 µg/mL
Incubation Time:

1 h (pre-incubation); 6 h (scratch monitoring)
Result:

Restored LPS-inhibited IEC-6 cell migration capacity to near control levels, as measured by relative migration index.

In Vivo

DOPE GMP (1 mg/kg; p.o.; 3 times daily; 4 days) reduces mortality, lowers NEC pathological injury scores, inhibits intestinal inflammation, restores intestinal barrier and proliferative function, and upregulates anti-ferroptosis marker GPX4 in neonatal SD rats with experimentally induced NEC^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (SD) Rat (neonatal, within 24 hours after birth, experimentally induced NEC)^[1]
Dosage:

1 mg kg^-1
Administration:

p.o.; 3 times daily; 4 days
Result:

Reduced neonatal rat mortality compared to the NEC-only group.
Significantly decreased the NEC pathological injury score of the terminal ileum.
Reduced relative mRNA expression of IL-1β and IL-6 in terminal ileum tissue.
Increased relative mRNA expression of tight junction proteins ZO-1 and occludin in terminal ileum tissue.
Improved intestinal epithelial proliferative ability compared to the NEC-only group.
Upregulated relative mRNA expression of the anti-ferroptosis factor GPX4 in terminal ileum tissue.
Reduced malondialdehyde (MDA) concentrations in terminal ileum tissue.

Chemical Information

No. CAS 4004-05-1
Peso molecular 744.03
Fòrmula C₄₁H₇₈NO₈P
SMILES

O=P(OC[C@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)(OCCN)O
Synonyms

Dioleoylphosphatidylethanolamine (GMP); 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (GMP)
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Chen Y, et al. Human breast milk-derived phospholipid DOPE ameliorates intestinal injury associated with NEC by inhibiting ferroptosis. Food Funct. 2024;15(21):10811-10822. Published 2024 Oct 28. [Content Brief]

[2]. Hariawan B S, et al. Development of liposomal amniotic mesenchymal stem cell metabolite products (AMSC-MP) loaded-scaffold for in vitro osteogenesis induction[J]. European Polymer Journal, 2024, 220: 113482.

[3]. Bae Y, et al. DQAsomes Nanoparticles Promote Osteogenic Differentiation of Human Adipose‐derived Mesenchymal Stem Cells[J]. Bulletin of the Korean Chemical Society, 2018, 39(1): 97-104.

[4]. Cui GH, et al. RVG-modified exosomes derived from mesenchymal stem cells rescue memory deficits by regulating inflammatory responses in a mouse model of Alzheimer's disease. Immun Ageing. 2019;16:10. Published 2019 May 13. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MOQ

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100 mg

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Actividad biológica
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- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias

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DOPE (GMP)

Ver todos los productos específicos de isoformas Glutathione Peroxidase

Ver todos los productos específicos de isoformas ACSL Family

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

DOPE (GMP) Related Classifications

HY-112005G Related Classifications