DS01080522
DS01080522 is a Protein Kinase cAMP-Activated Catalytic Subunit Alpha (PRKACA) inhibitor. DS01080522 inhibits PRKACA kinase activity and CREB phosphorylation with IC50s of 0.8 nM and 66 nM, respectively. DS01080522 can be used for the research of cancer.
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- No. CAS: 2832159-84-7
- Fòrmula: C23H20Cl2N4O3
- Peso molecular:471.34
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
IC50: 0.8 nM (PRKACA kinase), 66 nM (CREB phosphorylation)[1]
DS01080522 (1-10 μM; 30 min) affects phosphorylation of CREB[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NIH/3T3 cells
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Concentration:1-10 μM
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Incubation Time:30 min
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Result:Dose-dependently decreased the phosphorylation level of CREB which is a marker of intracellular PRAKACA inhibitory activity in NIH/3T3 cells with an IC50 value of 66 nM.
Chemical Information
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No. CAS 2832159-84-7
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Peso molecular 471.34
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Fòrmula C23H20Cl2N4O3
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SMILES
O=C(N[C@H]([C@@]1([H])C[C@H](O)CN1)C2=CC(Cl)=C(C#N)C=C2)C3=CC4=CC=NC(Cl)=C4C=C3OC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DS01080522 Related Classifications
HY-150073 Related Classifications
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