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EOS006215

(Synonyms: EOS-215)
Revisión del cliente

Based on 1 Customer Validation

EOS006215 (EOS-215) is a humanized monoclonal antibody targeting TREM-2. EOS006215 competes with TREM2 ligands, prevents TREM2 multimerization, and blocks downstream signaling. EOS006215 inhibits efferocytosis, reprograms transcriptomic profiles of monocyte-derived macrophages, alters metabolism and immune response genes, and increases pro-inflammatory marker secretion. EOS006215 reduces metastasis burden, delays tumor growth, and reprograms the tumor microenvironment to overcome anti-PD-1 resistance. EOS006215 can be used for the research of triple negative breast cancer and colorectal cancer.

Para uso exclusivo en investigación. No vendemos a pacientes.

  • Pureza: 98.47%
  • Peso molecular:146.57 kDa
  • Almacenamiento:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for EOS006215
  • Experimental Validation Results for EOS006215
  • EOS006215 Chemical Structure
    EOS006215 Chemical Structure
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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EOS006215 Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Encuentre su distribuidor local Your local distributor: Hycultec GmbHHycultec
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  • 1/16

    Product Image

  • 1/16

    Immobilized TREM-2 Protein, Human (HEK293, HY-P70534) can bind EOS006215, The ED50 for this effect is 885.5 ng/mL.

  • EOS006215 Chemical Structure
    1/16
  • EOS006215
  • Immobilized TREM-2 Protein, Human (HEK293, HY-P70534) can bind EOS006215, The ED50 for this effect is 885.5 ng/mL.
  • Product Image