EOS006215
Based on 1 Customer Validation
EOS006215 (EOS-215) is a humanized monoclonal antibody targeting TREM-2. EOS006215 competes with TREM2 ligands, prevents TREM2 multimerization, and blocks downstream signaling. EOS006215 inhibits efferocytosis, reprograms transcriptomic profiles of monocyte-derived macrophages, alters metabolism and immune response genes, and increases pro-inflammatory marker secretion. EOS006215 reduces metastasis burden, delays tumor growth, and reprograms the tumor microenvironment to overcome anti-PD-1 resistance. EOS006215 can be used for the research of triple negative breast cancer and colorectal cancer.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 98.47%
- Peso molecular:146.57 kDa
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
[1]|
TREM-2 |
In Vitro
EOS006215 competes with phosphatidylserine and low density lipoprotein for binding to TREM2, and blocks TREM2 multimerization necessary for downstream signaling[1].
EOS006215 potently inhibits efferocytosis by macrophages, a pathway linked to pro-tumoral macrophage functions, lipid associated macrophage development, and metastatic niche formation[1].
EOS006215 reprograms the transcriptomic profile of monocyte-derived macrophages, enriching gene sets linked to metabolism and immune response regulation, and increases macrophage secretion of pro-inflammatory markers[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- Multiplex immunofluorescence IHC
- Patient-Derived Xenograft (PDX)
- Multiplex immunohistochemistry
- Patient-Derived Orthotopic Xenograft (PDOX)
- Research Protocol for Inflammation-related Diseases
- Subcutaneous Cell-Line-Derived Xenograft
- Breast Cancer Modeling
- Orthotopic Cell-Line Xenograft
- Research Protocol for Cancer Immunology
Gene ID
Accession
Q9NZC2-1
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Aplicación
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized TREM-2 Protein, Human (HEK293, HY-P70534) can bind EOS006215, The ED50 for this effect is 885.5 ng/mL.
Chemical Information
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Appearance Liquid
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Peso molecular 146.57 kDa
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Color Colorless to light yellow
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SMILES
N/A
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Synonyms
EOS-215
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Envío
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EOS006215 Related Classifications
HY-P991621 Related Classifications
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