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Referencia número: HY-150536

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EP39

EP39 is a potent HIV-1 maturation inhibitor. EP39 interacts with the SP1 domain of Gag. EP39 decreases the dynamics of CA-SP1 junction, by binding to the QVT motif of the SP1 domain, and perturbs the natural coil-helix equilibrium on both sides of the SP1 domain by stabilizing the transient alpha helical structure. EP39 acts by arresting maturation of HIV-1 thereby blocking its infectivity.

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Fòrmula: C₃₈H₆₂N₂O₅
Peso molecular:626.91

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

EP39 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas HIV :

In Vitro

EP39 has binding affinity to different residues of SP1. SP1-T²³⁹ has the highest binding affinity (52.4 μM); SP1-S²³⁶, SP1-Q²³⁷ and SP1-V²³⁸ have relatively high binding affinities (179.6 μM, 154,5 μM and 204.4 μM, respectively); SP1-E²³³, SP1-M²³⁵ and NC-T²⁵⁷ have medium binding affinities (237.0 μM, 235,4 μM, 308.4 μM, respectively); CA-V²²¹, CA-L²³¹ and SP1-A²³² have weak binding affinities (669.6 μM, 678.4 μM and 691.9 μM, respectively) ^[1].
EP39 perturbs the natural coil-helix equilibrium on both sides of the SP1 domain by stabilizing the transient alpha helical structure^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Peso molecular 626.91
Fòrmula C₃₈H₆₂N₂O₅
SMILES

NCCNC([C@]12C([C@@H](CC2)C(C)=C)C3[C@@](CC1)([C@]4(C([C@@]5(C(C(C)([C@H](CC5)OC(CC(C)(C)C(O)=O)=O)C)CC4)C)CC3)C)C)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Chen X, et, al. The HIV-1 maturation inhibitor, EP39, interferes with the dynamic helix-coil equilibrium of the CA-SP1 junction of Gag. Eur J Med Chem. 2020 Oct 15;204:112634. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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