FR 409
FR 409 (NOR3) is a NO donor and vasodilator. FR 409 increases the diameter of retinal arterioles. FR 409 is toxic to a variety of cells. FR 409 can be used in research on pain and retinopathy.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 138472-01-2
- Fòrmula: C8H13N3O4
- Peso molecular:215.21
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
Descripciòn
In Vitro
FR 409 (50-100 μM; 17-25 h) is toxic to PC12, NIH-3T3, and MDA-MB-231 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
FR 409 (0.5–10 µg/kg/min; i.v.; single dose) increases the diameter of retinal arterioles and decreases mean arterial pressure in rats in a dose-dependent manner[3].
FR 409 (5 nM/eye; i.v.; single dose) increases the diameter of retinal arterioles in Wistar rats, but does not change mean arterial pressure or heart rate[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57BL/6 mice (Male, 7-10 weeks old)[1]
-
Dosage:2 mM
-
Administration:i.t.; single dose
-
Result:Induced cortical enhancement and mechanical hyperalgesia.
-
Animal Model:Wistar rats (male, 7–9 weeks old)[4]
-
Dosage:5 nM/eye
-
Administration:i.v.; single dose
-
Result:Increased the retinal arteriolar diameter without changing the mean arterial pressure and heart rate.
Chemical Information
-
No. CAS 138472-01-2
-
Peso molecular 215.21
-
Fòrmula C8H13N3O4
-
SMILES
NC(C(/C=C(CC)/C([N+]([O-])=O)C)=N/O)=O
-
Synonyms
NOR 3
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Onishi T, et al. Acute spatial spread of NO-mediated potentiation during hindpaw ischaemia in mice. J Physiol. 2019 Jul;597(13):3441-3455. [Content Brief]
[2]. Tsurukawa Y, et al. Mechanism of Action and Anti-Inflammatory Activity of Pestalotioquinol A, a Fungus-Derived Cytoprotective Compound. ACS Omega. 2025 Oct 8;10(41):49243-49251. [Content Brief]
[3]. Mori A, et al. 4-Aminopyridine, a Voltage-Gated K+ Channel Inhibitor, Attenuates Nitric Oxide-Mediated Vasodilation of Retinal Arterioles in Rats. Biol Pharm Bull. 2020;43(7):1123-1127. [Content Brief]
[4]. Mori A, et al. Role of Prostaglandins in Nitric Oxide-Induced Glial Cell-Mediated Vasodilation in Rat Retina. Biomolecules. 2022 Oct 1;12(10):1403. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FR 409 Related Classifications
HY-110057 Related Classifications
Powered by Bioz