GB1908
Based on 1 Customer Validation
GB1908 is a selective and orally active galectin-1 inhibitor with Ki values of 57 nM and 72 nM for human and mouse galectin-1, respectively. GB1908 displays >50-fold selectivity over galectin-3. GB1908 can be used for the study of lung cancer.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.94%
- No. CAS: 2573135-31-4
- Fòrmula: C18H18Cl2N4O5S2
- Peso molecular:505.40
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Ver todos los productos específicos de isoformas Galectin
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Actividad biológica
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Galectin-1 57 nM (Ki, Human galectin-1) |
Galectin-1 72 nM (Ki, Mouse galectin-1) |
Galectin-3 6000 nM (Ki, Human galectin-3) |
Galectin-3 4200 nM (Ki, Mouse galectin-3) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Jurkat | IC50 |
>8 μM
Compound: 5d
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Inhibition of apoptosis in galectin-3-induced human Jurkat cells measured after 16 hrs by caspase-3/7 green fluorescence based analysis
Inhibition of apoptosis in galectin-3-induced human Jurkat cells measured after 16 hrs by caspase-3/7 green fluorescence based analysis
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[PMID: 38804039] |
| Jurkat | IC50 |
0.85 μM
Compound: 5d
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Inhibition of apoptosis in galectin-1-induced human Jurkat cells measured after 16 hrs by caspase-3/7 green fluorescence based analysis
Inhibition of apoptosis in galectin-1-induced human Jurkat cells measured after 16 hrs by caspase-3/7 green fluorescence based analysis
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[PMID: 38804039] |
GB1908 (0.1-10 μM; 16 h) inhibits galectin-1-induced apoptosis in Jurkat cells (IC50 of 850 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Jurkat cells treatment with galectin-1
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Concentration:0.1-10 μM
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Incubation Time:16 h
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Result:Inhibited galectin-1-induced apoptosis.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female C57BL/6N mice injected with LL/2 (LLC1) Lewis lung carcinoma cells[1]
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Dosage:30 mg/kg (PEG300/Solutol HS15/Tween 20 solution (85/15/1% v/v))
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Administration:po; twice a day; for 21 days
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Result:Significantly inhibited tumor growth.
Chemical Information
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No. CAS 2573135-31-4
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Appearance Solid
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Peso molecular 505.40
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Fòrmula C18H18Cl2N4O5S2
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Color Off-white to light yellow
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SMILES
ClC1=CC(S[C@H]2O[C@H](CO)[C@H](O)[C@H](N3C=C(C4=CSC(O)=N4)N=N3)[C@H]2OC)=CC=C1Cl
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 100 mg/mL (197.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.95 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.95 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9786 mL | 9.8932 mL | 19.7863 mL | 49.4658 mL |
| 5 mM | 0.3957 mL | 1.9786 mL | 3.9573 mL | 9.8932 mL | |
| 10 mM | 0.1979 mL | 0.9893 mL | 1.9786 mL | 4.9466 mL | |
| 15 mM | 0.1319 mL | 0.6595 mL | 1.3191 mL | 3.2977 mL | |
| 20 mM | 0.0989 mL | 0.4947 mL | 0.9893 mL | 2.4733 mL | |
| 25 mM | 0.0791 mL | 0.3957 mL | 0.7915 mL | 1.9786 mL | |
| 30 mM | 0.0660 mL | 0.3298 mL | 0.6595 mL | 1.6489 mL | |
| 40 mM | 0.0495 mL | 0.2473 mL | 0.4947 mL | 1.2366 mL | |
| 50 mM | 0.0396 mL | 0.1979 mL | 0.3957 mL | 0.9893 mL | |
| 60 mM | 0.0330 mL | 0.1649 mL | 0.3298 mL | 0.8244 mL | |
| 80 mM | 0.0247 mL | 0.1237 mL | 0.2473 mL | 0.6183 mL | |
| 100 mM | 0.0198 mL | 0.0989 mL | 0.1979 mL | 0.4947 mL |
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