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Referencia número: HY-122018

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GS-9148

GS-9148 is a ribose-modified HIV-1 nucleotide reverse transcriptase (RT) inhibitor with an EC₅₀ value of 10.6 µM. GS-9148 shows antiretroviral activity for K65R, L74V, or M184V RT mutation.

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No. CAS: 875608-25-6
Fòrmula: C₁₀H₁₁FN₅O₅P
Peso molecular:331.20

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

GS-9148 Chemical Structure

No. CAS: 875608-25-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas HIV :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	CC₅₀	182 μM Compound: GS-9148	Cytotoxicity against CHO cells after 120 hrs by Cell-Titer Glo assay Cytotoxicity against CHO cells after 120 hrs by Cell-Titer Glo assay	[PMID: 19001108]
CHO	CC₅₀	≥4.5 μM Compound: GS-9148	Ratio of CC50 for CHO cells to CC50 for CHO cells expressing hOAT1 after 120 hrs by Cell-Titer Glo assay Ratio of CC50 for CHO cells to CC50 for CHO cells expressing hOAT1 after 120 hrs by Cell-Titer Glo assay	[PMID: 19001108]
CHO	CC₅₀	≥95 μM Compound: GS-9148	Cytotoxicity against CHO cells expressing hOAT1 after 120 hrs by Cell-Titer Glo assay Cytotoxicity against CHO cells expressing hOAT1 after 120 hrs by Cell-Titer Glo assay	[PMID: 19001108]
MT2	EC₅₀	12.3 μM Compound: 1, GS-9148, 2'-Fd4AP	Antiviral activity against HIV1 3B in MT2 cells Antiviral activity against HIV1 3B in MT2 cells	[PMID: 18082402]
MT2	CC₅₀	>1000 μM Compound: 1, GS-9148, 2'-Fd4AP	Cytotoxicity against human MT2 cells Cytotoxicity against human MT2 cells	[PMID: 18082402]
MT2	EC₅₀	12.3 μM Compound: 4, 2'-Fd4AP	Antiviral activity against wild type HIV1 3B in MT2 cells Antiviral activity against wild type HIV1 3B in MT2 cells	[PMID: 18164198]
MT2	IC₅₀	1.9 μM Compound: 4, 2'-Fd4AP	Inhibition of wild type HIV 3B reverse transcriptase in MT2 cells Inhibition of wild type HIV 3B reverse transcriptase in MT2 cells	[PMID: 18164198]
MT2	CC₅₀	>1000 μM Compound: 4, 2'-Fd4AP	Cytotoxicity against human MT2 cells Cytotoxicity against human MT2 cells	[PMID: 18164198]
MT2	EC₅₀	12 μM Compound: 3, GS-9148	Antiviral activity against HIV1 3a infected human MT2 cells assessed as inhibition of viral-induced cytopathic effect after 3 days by XTT assay Antiviral activity against HIV1 3a infected human MT2 cells assessed as inhibition of viral-induced cytopathic effect after 3 days by XTT assay	[PMID: 19179082]
MT2	CC₅₀	>1000 μM Compound: 3, GS-9148	Cytotoxicity against human MT2 cells after 5 days Cytotoxicity against human MT2 cells after 5 days	[PMID: 19179082]
MT2	EC₅₀	10600 nM Compound: 4, 2'-Fd4AP, GS-9148	Antiviral activity against HIV1 3B infected in human MT2 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by XTT assay Antiviral activity against HIV1 3B infected in human MT2 cells assessed as inhibition of virus-induced cytopathic effect after 5 days by XTT assay	[PMID: 20409721]
MT2	CC₅₀	>100000 nM Compound: 4, 2'-Fd4AP, GS-9148	Cytotoxicity against human MT2 cells after 5 days by XTT assay Cytotoxicity against human MT2 cells after 5 days by XTT assay	[PMID: 20409721]

Chemical Information

No. CAS 875608-25-6
Peso molecular 331.20
Fòrmula C₁₀H₁₁FN₅O₅P
SMILES

OP(O)(CO[C@H]1O[C@H](C(F)=C1)N2C=NC3=C(N=CN=C23)N)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Cihlar T, et al. Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131. Antimicrob Agents Chemother. 2008 Feb;52(2):655-65. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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