Hexoprenaline
Based on 1 Customer Validation
Hexoprenaline is an orally active and selective β-adrenergic receptor agonist. Hexoprenaline can dilate the bronchi. Hexoprenaline can activate adenylate cyclase and increases 14C-Aminopyrine uptake. Hexoprenaline exhibits anti-infection and anti-inflammmation effect. Hexoprenaline can increase placental weight and blood flow. Hexoprenaline can be used for the researches of inflammation, immunology, infection, endocrinology and neurological disease, such as asthma, chronic bronchitis, sepsis and intoxication of organophosphorus compounds.
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- Pureza: 96.0%
- No. CAS: 3215-70-1
- Fòrmula: C22H32N2O6
- Peso molecular:420.50
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Actividad biológica
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β-adrenoceptor |
Hexoprenaline (10 nM-1 mM) activates adenylate cyclase in isolated rat gastric mucosal cells[2].
Hexoprenaline (10-10000 nM) increasingly stimulate 14C-Aminopyrine uptake in isolated rat gastric mucosal cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Hexoprenaline (0.5 mg diet, p.o., daily) increases placental weight and blood flow in blood flow[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice with E. coli O157:H7-induced sepsis[3]
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Dosage:1.5 mg/kg
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Administration:Subcutaneous injection
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Result:Reduced the mortality by 1.98-fold at 4 h and by 1.56-fold at 24 h.
Decreased plasma TNF-α, IL-1β, and IL-6 concentrations.
Chemical Information
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No. CAS 3215-70-1
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Appearance Solid
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Peso molecular 420.50
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Fòrmula C22H32N2O6
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Color Light brown to brown
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SMILES
OC(CNCCCCCCNCC(O)C1=CC=C(C(O)=C1)O)C2=CC=C(C(O)=C2)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (269 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Schonell M, et al. Bronchodilator effect of hexoprenaline aerosol in bronchial asthma and chronic bronchitis. Med J Aust. 1977 Dec 17;2(25):828-30. [Content Brief]
[2]. Ruoff HJ, et al. Adrenergic stimulation of isolated rat gastric mucosal cells. Effect on adenylate cyclase and 14C-aminopyrine uptake. Naunyn Schmiedebergs Arch Pharmacol. 1982 Aug;320(2):175-81. [Content Brief]
[5]. Lipshitz J, et al. Effect of long-term administration of beta 2-sympathomimetic drug in the diet-restricted pregnant rat model. Am J Obstet Gynecol. 1986 Feb;154(2):314-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hexoprenaline Related Classifications
HY-121185 Related Classifications
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