HZ52
HZ52 is a potent, reversible 5-lipoxygenase inhibitor, blocking leukotriene synthesis with an IC50 of 0.7 μM in intact human polymorphonuclear leukocytes.
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- No. CAS: 1077626-51-7
- Fòrmula: C24H26ClN3O2S
- Peso molecular:456.00
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
1.6 μM
Compound: 7a
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Inhibition of PGES1 in human A549 cell microsome assessed as PGE2 formation by cell-free assay
Inhibition of PGES1 in human A549 cell microsome assessed as PGE2 formation by cell-free assay
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[PMID: 19053751] |
| PMNL | IC50 |
0.7 μM
Compound: 7a
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Inhibition of 5-LO in PMNL cells
Inhibition of 5-LO in PMNL cells
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[PMID: 19053751] |
Chemical Information
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No. CAS 1077626-51-7
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Peso molecular 456.00
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Fòrmula C24H26ClN3O2S
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SMILES
ClC1=CC(NC2=CC=C(C=C2)C3=CC=CC=C3)=NC(SC(C(O)=O)CCCCCC)=N1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HZ52 Related Classifications
HY-112553 Related Classifications
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