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Referencia número: HY-176938A

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iAfaPhos1

iAfaPhos1 is a FKBP12F36V epimer ligand. iAfaPhos1 leads to reduced dephosphorylation of EGFR at pY1068 and pY845 sites. iAfaPhos1 has anticancer activity against non-small cell lung cancer.

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Fòrmula: C₆₄H₇₇ClFN₇O₁₄
Peso molecular:1222.79

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

iAfaPhos1 Chemical Structure

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Antibody-Drug Conjugates

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Actividad biológica

Descripciòn

iAfaPhos1 is a FKBP12F36V epimer ligand. iAfaPhos1 leads to reduced dephosphorylation of EGFR at pY1068 and pY845 sites. iAfaPhos1 has anticancer activity against non-small cell lung cancer^[1].

Ver todos los productos específicos de isoformas EGFR :

Chemical Information

Peso molecular 1222.79
Fòrmula C₆₄H₇₇ClFN₇O₁₄
SMILES

O=C(COC1=CC([C@@H](CCC2=CC=C(C(OC)=C2)OC)OC([C@H]3CCCCN3C([C@H](C4=CC(OC)=C(C(OC)=C4)OC)CC)=O)=O)=CC=C1)NCCOCCOCCN(C/C=C/C(NC5=CC6=C(C=C5OC)N=CN=C6NC7=CC=C(C(Cl)=C7)F)=O)C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Hu Z, et al. EGFR targeting PhosTACs as a dual inhibitory approach reveals differential downstream signaling. Sci Adv. 2024 Mar 29;10(13):eadj7251. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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iAfaPhos1

Ver todos los productos específicos de isoformas EGFR

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

iAfaPhos1 Related Classifications

HY-176938A Related Classifications