Inaxaplin
Based on 1 Customer Validation
Inaxaplin (VX-147) is an orally active apolipoprotein L1 (APOL1) function inhibitor (WO2020131807, compound 2). Inaxaplin can be used for the research of kidney disease.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.44%
- No. CAS: 2446816-88-0
- Fòrmula: C21H18F3N3O3
- Peso molecular:417.38
-
Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
Metabolism/Protease Compound Library
HY-L012
-
Clinical Compound Library
HY-L026
-
Drug Repurposing Compound Library
HY-L035
-
Orally Active Compound Library
HY-L061
-
Heterocyclic Compound Library
HY-L138
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Drug Repurposing Compound Library Plus
HY-L035P
-
Clinical Compound Library Plus
HY-L026P
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
Actividad biológica
APOL1[1]
Inaxaplin is an apolipoprotein L1 function inhibitor[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
No. CAS 2446816-88-0
-
Appearance Solid
-
Peso molecular 417.38
-
Fòrmula C21H18F3N3O3
-
Color White to off-white
-
SMILES
O[C@H](CNC1=O)[C@@H]1NC(CCC(C2=CC(F)=C3)=C(C4=CC=C(C=C4)F)NC2=C3F)=O
-
Synonyms
VX-147
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 50 mg/mL (119.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
-
Ficha de datos (272 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
[1]. WO2020131807
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3959 mL | 11.9795 mL | 23.9590 mL | 59.8975 mL |
| 5 mM | 0.4792 mL | 2.3959 mL | 4.7918 mL | 11.9795 mL | |
| 10 mM | 0.2396 mL | 1.1979 mL | 2.3959 mL | 5.9897 mL | |
| 15 mM | 0.1597 mL | 0.7986 mL | 1.5973 mL | 3.9932 mL | |
| 20 mM | 0.1198 mL | 0.5990 mL | 1.1979 mL | 2.9949 mL | |
| 25 mM | 0.0958 mL | 0.4792 mL | 0.9584 mL | 2.3959 mL | |
| 30 mM | 0.0799 mL | 0.3993 mL | 0.7986 mL | 1.9966 mL | |
| 40 mM | 0.0599 mL | 0.2995 mL | 0.5990 mL | 1.4974 mL | |
| 50 mM | 0.0479 mL | 0.2396 mL | 0.4792 mL | 1.1979 mL | |
| 60 mM | 0.0399 mL | 0.1997 mL | 0.3993 mL | 0.9983 mL | |
| 80 mM | 0.0299 mL | 0.1497 mL | 0.2995 mL | 0.7487 mL | |
| 100 mM | 0.0240 mL | 0.1198 mL | 0.2396 mL | 0.5990 mL |
Inaxaplin Related Classifications
HY-132820 Related Classifications
Powered by Bioz