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Referencia número: HY-P99671

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Isecarosmab

Name: Isecarosmab
Brand: MedChemExpress
SKU: HY-P99671
Price: 280.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: M-6495)

Revisión del cliente

Based on 1 Customer Validation

Isecarosmab (M-6495) is an anti-ADAMTS monoclonal antibody (mAb) with a K_D value of 3.65 pM. Isecarosmab has chondroprotective and anti-inflammatory activities. Isecarosmab can bind albumin to extend plasma half-life.

Para uso exclusivo en investigación. No vendemos a pacientes.

Pureza : 96.95%
No. CAS: 2254082-79-4
Peso molecular:28.89 kDa

Almacenamiento:

Shipping with dry ice

Please store the product under the recommended conditions in the Certificate of Analysis.

Isecarosmab Chemical Structure

No. CAS: 2254082-79-4

Tamaño

Precio

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Cantidad

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Isotype
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Ensayo clínico
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Aplicación
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Isotype

VH-VH'

Species Reactivity

Human

IC₅₀ & Target

ALB & ADAMTSL5

In Vitro

Isecarosmab binds ADAMTS-5, but not ADAMTS-1, ADAMTS-4 and ADAMTS-15^[1].
Isecarosmab (1-100 nM, 5 days) decreases huARGS, exAGNxI and GAG after pro-inflammatory stimulation in the bovine and OA human cartilage explants^[1].
Isecarosmab (24-72 h) blocks ADAMTS-5-mediated DCS TLR2 activation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Isecarosmab (0.1-10 mg/kg mg/kg, s.c, every third day) decreases the medial cartilage degeneration in Medial meniscus (DMM) mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Ensayo clínico

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991			2011-05	PHASE1

Gene ID

704892 [NCBI] & 339366 [NCBI]

Accession

Q28522 & Q6ZMM2

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

VH-VH'

Aplicación

ELISA, FACS, Functional assay

Chemical Information

No. CAS 2254082-79-4
Appearance Liquid
Peso molecular 28.89 kDa
Color Colorless to light yellow
SMILES

[Isecarosmab]
Synonyms

M-6495
Envío

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (258 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Referencias

[1]. Siebuhr AS, et al. The Anti-ADAMTS-5 Nanobody® M6495 Protects Cartilage Degradation Ex Vivo. Int J Mol Sci. 2020 Aug 20;21(17):5992. [Content Brief]

[2]. Sharma N, et al. Inflammation and joint destruction may be linked to the generation of cartilage metabolites of ADAMTS-5 through activation of toll-like receptors. Osteoarthritis Cartilage. 2020 May;28(5):658-668. [Content Brief]

[3]. C. Brenneis. Structural and symptomatic benefit of a half-live extended, systemically applied anti-ADAMTS-5 inhibitor (M6495). 2018. 26 (1), S299-S300.

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Actividad biológica
- Descripciòn
- Isotype
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Ensayo clínico
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Aplicación
Chemical Information
Pureza y Documentación
Referencias

Nombre del producto:
Referencia número:
Cantidad:
MCE Japan Authorized Agent:

Nombre del producto:
No. CAS:
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Pureza:
Cantidad:

Isecarosmab

Bradford Protein Assay Kit

Cell-ATP Viability Detection Kit

Protein A Agarose

HOLO Human Interleukin-2 (IL-2) Detection Kit

PBS Buffer (1×)

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit